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Titolo:
Clinical usefulness of telomerase assay for the detection of lymph node metastasis in patients with oral malignancy
Autore:
Sumida, T; Hamakawa, H; Kayahara, H; Zen, H; Sogawa, K; Tanioka, H; Ueda, N;
Indirizzi:
Ehime Univ, Sch Med, Dept Oral Surg, Shigenobu, Ehime 7910295, Japan EhimeUniv Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Ehime Univ, Sch Med, Dept Pathol 1, Matsuyama, Ehime 790, Japan Ehime Univ Matsuyama Ehime Japan 790 athol 1, Matsuyama, Ehime 790, Japan Univ Tokushima, Sch Med, Dept Surg 1, Tokushima 770, Japan Univ TokushimaTokushima Japan 770 ed, Dept Surg 1, Tokushima 770, Japan
Titolo Testata:
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
fascicolo: 3, volume: 124, anno: 2000,
pagine: 398 - 400
SICI:
0003-9985(200003)124:3<398:CUOTAF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; KERATIN-19 MESSENGER-RNA; SQUAMOUS-CELL CARCINOMA; EXFOLIATED CANCER-CELLS; TUMOR-CELLS; RT-PCR; MICROMETASTASES; KERATINOCYTES; AMPLIFICATION; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Sumida, T Ehime Univ, Sch Med, Dept Oral Surg, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 , Ehime 7910295, Japan
Citazione:
T. Sumida et al., "Clinical usefulness of telomerase assay for the detection of lymph node metastasis in patients with oral malignancy", ARCH PATH L, 124(3), 2000, pp. 398-400

Abstract

Objective.-Telomerase is considered a diagnostic marker of malignancy. We investigated the usefulness of telomerase assay for the detection of lymph node micrometastasis. Methods.-Sixteen cervical lymph nodes with metastasis of oral cancer and 20 benign lymph nodes were studied. The oral cancer cell line was used to estimate the sensitivity for telomerase assay. Telomerase activity was measured by semiquantitative telomeric repeat amplification protocol. Results.-There was a significant difference between malignant and benign lymph nodes. The telomerase activity of 50 mg of lymph nodes with 10(3) or more cancer cells differed from that of control lymph nodes. Lymph nodes with 10(2) or fewer tumor cells expressed similar levels as benign lymph nodes. Conclusions.-In addition to routine histologic examination, telomerase assay is considered a useful tool for the detection of lymph node metastasis in patients with oral malignancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:10:18