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Titolo:
Neuropsychological change in early phase schizophrenia during 12 months oftreatment with olanzapine, risperidone, or haloperidol
Autore:
Purdon, SE; Jones, BDW; Stip, E; Labelle, A; Addington, D; David, SR; Breier, A; Tollefson, GD;
Indirizzi:
Alberta Hosp Edmonton, Edmonton, AB T5J 2J7, Canada Alberta Hosp EdmontonEdmonton AB Canada T5J 2J7 nton, AB T5J 2J7, Canada Univ Alberta, Edmonton, AB, Canada Univ Alberta Edmonton AB CanadaUniv Alberta, Edmonton, AB, Canada McMaster Univ, Hamilton, ON, Canada McMaster Univ Hamilton ON CanadaMcMaster Univ, Hamilton, ON, Canada Eli Lilly Canada Inc, Scarborough, ON, Canada Eli Lilly Canada Inc Scarborough ON Canada Inc, Scarborough, ON, Canada Univ Montreal, Montreal, PQ, Canada Univ Montreal Montreal PQ CanadaUniv Montreal, Montreal, PQ, Canada Univ Ottawa, Ottawa, ON, Canada Univ Ottawa Ottawa ON CanadaUniv Ottawa, Ottawa, ON, Canada Royal Ottawa Hosp, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp Ottawa ONCanada K1Z 7K4 sp, Ottawa, ON K1Z 7K4, Canada Univ Calgary, Calgary, AB, Canada Univ Calgary Calgary AB CanadaUniv Calgary, Calgary, AB, Canada Eli Lilly & Co, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis INUSA 46285 & Co, Indianapolis, IN 46285 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 3, volume: 57, anno: 2000,
pagine: 249 - 258
SICI:
0003-990X(200003)57:3<249:NCIEPS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; COGNITIVE FUNCTIONS; CLOZAPINE; DEFICITS; SYMPTOMS; PERFORMANCE; MEDICATION; DOPAMINE; DISORDER; MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Purdon, SE Alberta Hosp Edmonton, Neuropsychol 9 Bldg,Room 148,Box 307,17480 Ft Rd, Edmonton, AB T5J 2J7, Canada Alberta Hosp Edmonton Neuropsychol 9Bldg,Room 148,Box 307,17480 Ft Rd Edmonton AB Canada T5J 2J7
Citazione:
S.E. Purdon et al., "Neuropsychological change in early phase schizophrenia during 12 months oftreatment with olanzapine, risperidone, or haloperidol", ARCH G PSYC, 57(3), 2000, pp. 249-258

Abstract

Background: The purpose of this investigation was to test the efficacy of novel antipsychotic medications in the treatment of cognitive impairment inearly phase schizophrenia. Methods: Sixty-five patients in this multicenter double-blind study were randomly assigned to olanzapine (5-20 mg), risperidone (4-10 mg), or haloperidol (5-20 mg). Standard measures of clinical and motor syndromes were administered, as well as a comprehensive battery of tests to assess (1) motor skills, (2) attention span, (3) verbal fluency and reasoning, (4) nonverbal fluency and construction, (5) executive skills, and (6) immediate recall atbaseline and after 6, 30, and 54 weeks of treatment. Results: The general cognitive index derived from the 6 domain scores revealed a significantly greater benefit from treatment with olanzapine relative to haloperidol and olanzapine relative to risperidone, but no significantdifference was shown between risperidone and haloperidol. The improvement related to olanzapine was apparent after 6 weeks and enhanced after 30 and 54 weeks of treatment. Exploratory within-group analyses of the 6 cognitivedomains after a conservative Bonferroni adjustment revealed a significant improvement with olanzapine only on the immediate recall domain, and similar analyses of the 17 individual tests revealed a significant improvement with olanzapine only on the Hooper Visual Organization Test. Conclusions: These data suggest that olanzapine has some superior cognitive benefits relative to haloperidol and risperidone. A larger sample replication study is necessary to confirm and generalize the observations of this study and begin evaluation of the implications of this change to cerebral function and quality of life for people with schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:35:30