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Titolo:
The resistance of human monocyte-derived macrophages to Chlamydia pneumoniae infection is enhanced by interferon-gamma
Autore:
Airenne, S; Surcel, HM; Bloigu, A; Laitinen, K; Saikku, P; Laurila, A;
Indirizzi:
Natl Publ Hlth Inst, FIN-90101 Oulu, Finland Natl Publ Hlth Inst Oulu Finland FIN-90101 Inst, FIN-90101 Oulu, Finland
Titolo Testata:
APMIS
fascicolo: 2, volume: 108, anno: 2000,
pagine: 139 - 144
SICI:
0903-4641(200002)108:2<139:TROHMM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPTOPHAN CATABOLISM; PSITTACI REPLICATION; MEDIATED INHIBITION; RABBIT MODEL; HEP-2 CELLS; TRACHOMATIS; LYMPHOKINE; GROWTH;
Keywords:
C. pneumoniae; human monocyte-derived macrophages; HL-cells; interferon-gamma; cell culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Laurila, A Natl Publ Hlth Inst, PL 310, FIN-90101 Oulu, Finland Natl Publ Hlth Inst PL 310 Oulu Finland FIN-90101 ulu, Finland
Citazione:
S. Airenne et al., "The resistance of human monocyte-derived macrophages to Chlamydia pneumoniae infection is enhanced by interferon-gamma", APMIS, 108(2), 2000, pp. 139-144

Abstract

Chlamydia pneumoniae is an intracellular bacterium which commonly causes respiratory infections. Chronic infections have been associated with atherosclerosis and the organism has been detected in macrophages in the disease lesions. Growth of chlamydiae in different epithelial cell lines is restricted by interferon-gamma (IFN-gamma), a monocyte activator produced by T cells. We have studied the influence of IFN-gamma on the growth and infectivityof C. pneumoniae in HL-cells and human monocyte-derived macrophages. Low concentrations of the cytokine significantly restricted the growth and productivity of C. pneumoniae in epithelial cells in vitro. In macrophages, however, no effect on the growth of the bacteria in infected cells was found, but high doses clearly restricted the production of infectious progeny. The results suggest that IFN-gamma participates in the resistance to C. pneumoniae. The bacterium is, however, still capable of infecting macrophages thatare important in the pathogenesis of atherosclerosis and it may thus participate in the inflammatory process associated with the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 12:52:20