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Titolo:
Sex differences in inferior parietal lobule volume in schizophrenia
Autore:
Frederikse, M; Lu, A; Aylward, E; Barta, P; Sharma, T; Pearlson, G;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Div Psychiat Neuroimaging, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287maging, Baltimore, MD 21287 USA Inst Psychiat, Sect Cognit Psychopharmacol, London SE5 8AF, England Inst Psychiat London England SE5 8AF opharmacol, London SE5 8AF, England
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 3, volume: 157, anno: 2000,
pagine: 422 - 427
SICI:
0002-953X(200003)157:3<422:SDIIPL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PLANUM TEMPORALE; GENDER DIFFERENCES; NEUROPSYCHOLOGICAL FUNCTIONS; CEREBRAL LATERALIZATION; PREFRONTAL CORTEX; BLOOD-FLOW; BRAIN; ASYMMETRY; HANDEDNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Pearlson, G Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Div Psychiat Neuroimaging, 600 N Wolfe St,Meyer 3-166, Baltimore, MD 21287 USA Johns Hopkins Univ 600 N Wolfe St,Meyer 3-166 Baltimore MD USA 21287
Citazione:
M. Frederikse et al., "Sex differences in inferior parietal lobule volume in schizophrenia", AM J PSYCHI, 157(3), 2000, pp. 422-427

Abstract

Objective: The inferior parietal lobule is a heteromodal association cortical region that has been implicated in the pathophysiology of schizophrenia. Inferior parietal lobule gray matter volumes have been shown to differ between healthy male and female subjects, with male subjects having larger left volumes. The authors sought to determine whether these volumetric sex differences also exist in patients with schizophrenia. Method: The authors used magnetic resonance imaging to measure inferior parietal lobule volumes of 15 pairs of male and female schizophrenic subjects who were individually matched to each other and to 15 pairs of healthy male and female subjects. Results: Male schizophrenic patients exhibited a reversal of the normal left-greater-than-right male asymmetry in this region and had left inferior parietal lobule gray matter volumes that were significantly smaller than those of healthy male subjects. Female schizophrenic patients did not differ significantly from healthy female subjects in left or right inferior parietallobule volume or in asymmetry. Conclusions: This study provides further evidence of brain morphology sex differences in schizophrenia that possibly contribute to the differential clinical disease expression in men and women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:25:08