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Titolo:
Structural brain abnormalities in patients with schizophrenia and their healthy siblings
Autore:
Staal, WG; Pol, HEH; Schnack, HG; Hoogendoorn, MLC; Jellema, K; Kahn, RS;
Indirizzi:
Univ Utrecht Hosp, Dept Psychiat, Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands pt Psychiat, Utrecht, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 3, volume: 157, anno: 2000,
pagine: 416 - 421
SICI:
0002-953X(200003)157:3<416:SBAIPW>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAY-MATTER VOLUME; PREFRONTAL CORTEX; NEUROLEPTIC-NAIVE; RESONANCE; CAUDATE; MRI; REDUCTION; THALAMUS; MORPHOLOGY; RELATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Staal, WG Univ Iowa, Dept Psychiat, MH CRC, 200 Hawkins Dr, Iowa City, IA 52242 USA Univ Iowa 200 Hawkins Dr Iowa City IA USA 52242 ty, IA 52242 USA
Citazione:
W.G. Staal et al., "Structural brain abnormalities in patients with schizophrenia and their healthy siblings", AM J PSYCHI, 157(3), 2000, pp. 416-421

Abstract

Objective: The authors sought to investigate the contribution of genotype on structural brain abnormalities in schizophrenia. Method: Intracranial volumes and volumes of the cerebrum, white and gray matter, lateral and thirdventricles, frontal lobes, caudate nucleus, amygdala, hippocampus, parahippocampal gyrus, and the cerebellum were measured in 32 same-sex siblings discordant for schizophrenia and 32 matched comparison subjects by means of magnetic resonance imaging. Results: Third ventricle volumes did not differ between the schizophrenic patients and their healthy siblings. However, both had higher third ventricle volumes than did the comparison subjects. The schizophrenic patients had lower cerebrum volumes than did the comparison subjects, whereas the cerebrum volume of the healthy siblings did not significantly differ from the patients or comparison subjects. Additionally, patients with schizophrenia displayed a volume reduction of the frontal lobe gray matter and a volume increase of the caudate nuclei and lateral ventricles compared to both their healthy siblings and comparison subjects. Intracranial volume, CSF volume, or volumes of the cerebellum, amygdala, hippocampus, or the parahippocampal gyrus did not significantly differ among the patients, siblings, and comparison subjects. Conclusions: Healthy siblings share third ventricle enlargement with their affected relatives and may partially display a reduction in cerebral volume. These findings suggest that third ventricular enlargement, and to some extent cerebral volume decrease, maybe related to genetic defects that produce a susceptibility to schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:52:37