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Titolo:
Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish study of high-density schizophrenia families
Autore:
Kendler, KS; Myers, JM; ONeill, FA; Martin, R; Murphy, B; MacLean, CJ; Walsh, D; Straub, RE;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychiat, Richmond, VA23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 t, Richmond, VA23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Human Genet, Richmond,VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 t, Richmond,VA 23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Mater Hosp, Dept Psychiat, Belfast, Antrim, North Ireland Mater Hosp Belfast Antrim North Ireland , Belfast, Antrim, North Ireland Hlth Res Board, Dublin, Ireland Hlth Res Board Dublin IrelandHlth Res Board, Dublin, Ireland
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 3, volume: 157, anno: 2000,
pagine: 402 - 408
SICI:
0002-953X(200003)157:3<402:CFOSAL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VULNERABILITY LOCUS; GENOME SCAN; SUSCEPTIBILITY LOCUS; ROSCOMMON FAMILY; SUBTYPES; REGION; HETEROGENEITY; PSYCHOSIS; SYMPTOMS; SIBLINGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kendler, KS Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychiat, Box 980710, Richmond, VA 23298 USA Virginia Commonwealth Univ Box 980710 Richmond VA USA 23298 SA
Citazione:
K.S. Kendler et al., "Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish study of high-density schizophrenia families", AM J PSYCHI, 157(3), 2000, pp. 402-408

Abstract

Objective: Schizophrenia is clinically heterogeneous. Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined the hypothesis of whether the clinical variabilityin schizophrenia is due to genetic heterogeneity. Method: Using data from the Irish Study of High-Density Schizophrenia Families (N = 265 pedigrees; N = 1,408 individuals), the authors attempted to predict, from major symptoms and signs of psychosis, evidence for linkage within families for schizophrenia-related disorders to chromosomal regions 5q21-5q31, 6p24-6p22, 8p22-8p21, and 10p15-10p11. Results: No substantial evidence was found for associations between clinical features of schizophrenia and linkage to chromosomes 50, 6p, or 10p. However, affected individuals from families with evidence for linkage to 8p had significantly more affective deterioration, poorer outcome, more thought disorder. and fewer depressive symptoms than affectedindividuals from the other families in the study. Conclusions: These results raise the possibility that the putative susceptibility gene for schizophrenia localized in the 8p22-8p21 region may predispose individuals to the core dementia-praecox syndrome described by Kraepelin more than 100 years ago.

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Documento generato il 31/05/20 alle ore 13:19:39