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Titolo:
Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells
Autore:
Suzuki, T; Yamaya, M; Sekizawa, K; Yamada, N; Nakayama, K; Ishizuka, S; Kamanaka, M; Morimoto, T; Numazaki, Y; Sasaki, H;
Indirizzi:
Tohoku Univ, Sch Med, Dept Geriatr & Resp Med, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Pediat, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Sendai Natl Hosp, Div Clin Res, Virus Ctr, Sendai, Miyagi 9830045, Japan Sendai Natl Hosp Sendai Miyagi Japan 9830045 endai, Miyagi 9830045, Japan Univ Tsukuba, Inst Clin Med, Dept Resp Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 3, volume: 278, anno: 2000,
pagine: L560 - L571
SICI:
1040-0605(200003)278:3<L560:EODORI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; COLONY-STIMULATING FACTOR; IN-VITRO; EXPRESSION; INDUCTION; RECEPTOR; ASTHMA; VIRUS; EXACERBATIONS; MECHANISMS;
Keywords:
asthma; common cold; airway inflammation; intercellular adhesion molecule-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, H Tohoku Univ, Sch Med, Dept Geriatr & Resp Med, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi SendaiMiyagi Japan 9808574 , Japan
Citazione:
T. Suzuki et al., "Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells", AM J P-LUNG, 278(3), 2000, pp. L560-L571

Abstract

To examine the effects of glucocorticoid on rhinovirus (RV) infection, primary cultures of human tracheal epithelial cells were infected with either RV2 or RV14. Viral infection was confirmed by demonstrating that viral RNA in infected cells and viral titers of supernatants and lysates from infected cells increased with time. RV14 infection upregulated the expression of mRNA and protein of intercellular adhesion molecule-1 (ICAM-1), the major RVreceptor, on epithelial cells, and it increased the production of interleukin (IL)-1 beta, IL-6, IL-8, and tumor necrosis factor-oc in supernatants. Dexamethasone reduced the viral titers of supernatants and cell lysates, viral RNA of infected cells, and susceptibility of RV14 infection in association with inhibition of cytokine production and ICAM-1 induction. In contrast to RV14 infection, dexamethasone did not alter RV2 infection, a minor group of RVs. These results suggest that dexamethasone may inhibit RV14 infection by reducing the surface expression of ICAM-1 in cultured human trachealepithelial cells. Glucocorticoid may modulate airway inflammation via reducing the production of proinflammatory cytokines and ICAM-1 induced by rhinovirus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:42:13