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Titolo:
Effect of bradykinin on membrane properties of guinea pig branchial parasympathetic ganglion neurons
Autore:
Kajekar, R; Myers, AC;
Indirizzi:
Johns Hopkins Univ, Ctr Asthma & Allergy, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 llergy, Baltimore, MD 21224 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 3, volume: 278, anno: 2000,
pagine: L485 - L491
SICI:
1040-0605(200003)278:3<L485:EOBOMP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLOW SPIKE AFTERHYPERPOLARIZATION; ELECTROPHYSIOLOGICAL PROPERTIES; NEUROPEPTIDE RELEASE; AFFERENT NEURONS; PROSTAGLANDIN-E; IN-VITRO; C-FIBERS; AIRWAYS; RECEPTORS; MECHANISM;
Keywords:
autonomic ganglia; airway; sensory nerves; intracellular recording; cyclooxygenase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Myers, AC Johns Hopkins Univ, Ctr Asthma & Allergy, 5501 Hopkins Bayview Circle,1A62, Baltimore, MD 21224 USA Johns Hopkins Univ 5501 Hopkins BayviewCircle,1A62 Baltimore MD USA 21224
Citazione:
R. Kajekar e A.C. Myers, "Effect of bradykinin on membrane properties of guinea pig branchial parasympathetic ganglion neurons", AM J P-LUNG, 278(3), 2000, pp. L485-L491

Abstract

The effect of bradykinin on membrane properties of parasympathetic ganglion neurons in isolated guinea pig bronchial tissue was studied using intracellular recording techniques. Bradykinin (1-100 nM) caused a reversible membrane potential depolarization of ganglion neurons that was not associated with a change in input resistance. The selective bradykinin Ba receptor antagonist HOE-140 inhibited bradykinin-induced membrane depolarizations. Furthermore, the cyclooxygenase inhibitor indomethacin attenuated bradykinin-induced membrane depolarizations to a similar magnitude (similar to 70%) as HOE-140. However,neurokinin-l and -3 receptor antagonists did not have similar inhibitory effects. The ability of bradykinin to directly alter active properties of parasympathetic ganglion neurons was also examined. Bradykinin (100 nM) significantly reduced the duration of the afterhyperpolarization AHP that followed four consecutive action potentials. The inhibitory,effect of bradykinin on the AHP response was reversed by HOE-140 but not by indomethacin. These results indicate that bradykinin can stimulate airway parasympathetic ganglion neurons independent of sensory nerve activation and provide an alternative mechanism for regulating airway parasympathetic tone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:37:29