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Titolo:
The I kappa B/NF-kappa B system: a key determinant of mucosal inflammationand protection
Autore:
Jobin, C; Sartor, RB;
Indirizzi:
Univ N Carolina, Dept Med, Div Digest Dis & Nutr, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Nutr, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 munol, Chapel Hill, NC 27599 USA Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 & Dis, Chapel Hill, NC 27599 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
fascicolo: 3, volume: 278, anno: 2000,
pagine: C451 - C462
SICI:
0363-6143(200003)278:3<C451:TIKBBS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL EPITHELIAL-CELLS; ADHESION MOLECULE-1 ICAM-1; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; UBIQUITIN-PROTEASOME PATHWAY; BOWEL-DISEASE; TRANSCRIPTION FACTOR; KINASE COMPLEX; FUNCTIONAL-CHARACTERIZATION; PROINFLAMMATORY CYTOKINES;
Keywords:
cytokines; signal transduction; bacteria; gene manipulation; intestinal epithelial cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
137
Recensione:
Indirizzi per estratti:
Indirizzo: Jobin, C Univ N Carolina, Dept Med, Div Digest Dis & Nutr, CB 7038,Glaxo Bldg, Chapel Hill, NC 27599 USA Univ N Carolina CB 7038,Glaxo Bldg Chapel Hill NC USA 27599 9 USA
Citazione:
C. Jobin e R.B. Sartor, "The I kappa B/NF-kappa B system: a key determinant of mucosal inflammationand protection", AM J P-CELL, 278(3), 2000, pp. C451-C462

Abstract

The ubiquitous transcription factor NF-kappa B is a central regulator of the transcriptional activation of a number of genes involved in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Induction of these genes in intestinal epithelial cells (IECs) by activated NF-kappa B profoundly influences mucosal inflammation and repair. NF-kappa B activation requires the removal of I kappa B from NF-kappa B by inducible proteolysis, which liberates this transcription factor for migration to the nucleus, where it binds to kappa B-regulatory elements and inducestranscription. I kappa B alpha degradation is incomplete and delayed in IECs, resulting in buffered responses to luminal stimuli. The stimulatory environment partially determines whether the effect of NF-kappa B is protective or deleterious for the host. kappa B-dependent proinflammatory gene expression, particularly chemokines, major histocompatibility complex class II antigens, and adhesion molecules may be extremely important in early protective responses to mucosal pathogens but, when dysregulated, could lead to the development of chronic inflammation, as seen in inflammatory bowel diseases. The key role of NF-kappa B in regulating expression of a number of proinflammatory genes makes this protein an attractive target for selective therapeutic intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:00:02