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Titolo:
Association between total homocyst(e)ine and the likelihood for a history of acute myocardial infarction by race and ethnicity: Results from the Third National Health and Nutrition Examination Survey
Autore:
Giles, WH; Croft, JB; Greenlund, KJ; Ford, ES; Kittner, SJ;
Indirizzi:
Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Cardiovasc Hlth Branch, Atlanta, GA 30341 USA Ctr Dis Control & Prevent AtlantaGA USA 30341 nch, Atlanta, GA 30341 USA Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Dept Neurol, CollegePk, MD 20742 USA Univ Maryland College Pk MD USA 20742 ept Neurol, CollegePk, MD 20742 USA Ctr Geriatr Res Educ & Clin, Baltimore, MD USA Ctr Geriatr Res Educ & Clin Baltimore MD USA c & Clin, Baltimore, MD USA Dept Vet Affairs Med Ctr, Baltimore, MD USA Dept Vet Affairs Med Ctr Baltimore MD USA irs Med Ctr, Baltimore, MD USA
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 3, volume: 139, anno: 2000,
pagine: 446 - 453
SICI:
0002-8703(200003)139:3<446:ABTHAT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ELEVATED PLASMA HOMOCYST(E)INE; RISK FACTOR; CARDIOVASCULAR-DISEASE; HOMOCYSTEINE METABOLISM; VASCULAR-DISEASE; HYPERHOMOCYST(E)INEMIA; VITAMIN-B12; STROKE; FOLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Giles, WH Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Cardiovasc Hlth Branch, 4770 Buford Hwy,MS K-47, Atlanta, GA 30341 USACtr Dis Control & Prevent 4770 Buford Hwy,MS K-47 Atlanta GA USA 30341
Citazione:
W.H. Giles et al., "Association between total homocyst(e)ine and the likelihood for a history of acute myocardial infarction by race and ethnicity: Results from the Third National Health and Nutrition Examination Survey", AM HEART J, 139(3), 2000, pp. 446-453

Abstract

Background Few studies examining the association between total homocyst(e)ine and coronary heart disease have included blacks or Hispanics. Methods Data from the third National Health and Nutrition Examination Survey (3173 patients), a nationally representative survey of US adults, were used to examine the relation between total homocyst(e)ine and an electrocardiogram or a physician's diagnosis of acute myocardial infarction (259 patients) among whites, blacks, and Mexican Americans greater than or equal to 40 years aid. Results Vitamin B-12 and serum folate concentrations were significantly lower among persons with a total homocyst(e)ine concentration greater than orequal to 15 mu mol/L than among those with a total homocyst(e)ine concentration less than or equal to 10 mu mol/L. Persons with a total homocyst(e)ine concentration greater than or equal to 15 mu mol/L were also older and more likely to be hypertensive, have a higher cholesterol concentration, and smoke. Compared with persons with a total homocyst(e)ine concentration lessthan or equal to 10 mu mol/L, persons with a concentration greater than orequal to 15 mu mol/L had an odds ratio (OR) for myocardial infarction of 1.8 (95% confidence interval [CI], 1.2-2.9) after adjustment for cardiovascular disease risk factors. Similar associations were noted among whites (OR 1.8, 95% CI, 1.1-3.1) and blacks (OR 1.9, 95% CI, 0.8-4.2); a more modest association was noted among Mexican Americans (OR 1.2, 95% CI, 0.3-5.0). Theassociation between total homocyst(e)ine and myocardial infarction was also more pronounced in persons without hypertension or diabetes. Conclusions Almost a 2-fold increased likelihood of myocardial infarction among persons with a total homocyst(e)ine concentration greater than or equal to 15 mu mol/L was noted in this nationally representative survey. The magnitude of the association did not differ by race or ethnicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:38:12