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Infusion versus bolus contrast echocardiography: A multicenter, open-label, crossover trial
Weissman, NJ; Cohen, MC; Hack, TC; Gillam, LD; Cohen, JL; Kitzman, DW;
Georgetown Med Ctr, Washington, DC USA Georgetown Med Ctr Washington DC USA rgetown Med Ctr, Washington, DC USA Maine Cardiol Assoc, Portland, ME USA Maine Cardiol Assoc Portland ME USA aine Cardiol Assoc, Portland, ME USA Primary Care Cardiol Inc, Ayer, MA USA Primary Care Cardiol Inc Ayer MA USA mary Care Cardiol Inc, Ayer, MA USA Hartford Hosp, Hartford, CT 06115 USA Hartford Hosp Hartford CT USA 06115Hartford Hosp, Hartford, CT 06115 USA New Jersey VA Med Ctr, E Orange, NJ USA New Jersey VA Med Ctr E Orange NJUSA ersey VA Med Ctr, E Orange, NJ USA Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA
Titolo Testata:
fascicolo: 3, volume: 139, anno: 2000,
pagine: 399 - 404
Tipo documento:
Settore Disciplinare:
Clinical Medicine
Life Sciences
Indirizzi per estratti:
Indirizzo: Weissman, NJ Cardiovasc Res Fdn, 110 Irving St,4B1, Washington, DC 20010 USA Cardiovasc Res Fdn 110 Irving St,4B1 Washington DC USA 20010
N.J. Weissman et al., "Infusion versus bolus contrast echocardiography: A multicenter, open-label, crossover trial", AM HEART J, 139(3), 2000, pp. 399-404


Background In current practice, contrast echocardiography is performed with single or multiple bolus injections, which often result in an uncontrolled period of attenuation followed by transient left ventricular opacification (LVO). Because a "slow bolus" appears to reduce attenuation and prolong LVO, we hypothesized that a controlled infusion of contrast might provide a more uniform contrast effect with less attenuation and longer contrast duration. Methods and Results We sought to test the hypothesis by using an infusion of contrast (DEFINITY [perflutren], The DuPont Pharmaceuticals Co, Medical Imaging, North Billerica, Mass) that is stable when diluted in saline in a randomized, multicenter, controlled, crossover trial. Sixty-four patients with poor noncontrast images were recruited at 3 centers and randomly assigned to 2 single "slow" bolus injections of contrast (10 mu L/kg each over a period of 30 to 60 seconds) or an infusion (1.3 mL in 50 mL normal saline initially at 4.0 mL/min) of contrast. Patients then returned within 24 to 72hours for the alternative form of contrast delivery. Three independent experienced echocardiographers viewed 30 seconds of videotape for all optimal baseline and optimal contrast images to score LVO and qualitatively assessed endocardial border evaluability. The duration of adequate LVO then was independently assessed by review of the entire videotape. Three independent sonographers traced single-frame, digitally captured images to measure the length of the contiguous endocardial border visualized. Both bolus and infusion administration demonstrated improved LVO (>90% by all blinded readers, P < .01) and endocardial border visualized (mean increase of 1.8 to 4.7 cm at both end-diastole and end-systole, all P < .05) as compared with baseline images. However, contrast infusion resulted in a longer duration of LVO (range of mean durations for each reader, 158 to 174 seconds longer, P < .05) and a shorter duration of attenuation (18 to 54 seconds, P < .05) compared with either bolus injection. There were no severe adverse events with contrast infusion. Conclusions Contrast echocardiography delivered as an infusion optimizes the contrast effect by decreasing the attenuation period, extending the LVO duration, and providing a uniform contrast effect that may be useful in obtaining multiple echocardiographic views, stress echocardiography, myocardial perfusion imaging, and applications in which blood flow must be quantified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 13:44:10