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Titolo:
MORTALITY PREDICTION IN DIABETIC-PATIENTS WITH MYOCARDIAL-INFARCTION - EXPERIENCES FROM THE DIGAMI STUDY
Autore:
MALMBERG K; RYDEN L; HAMSTEN A; HERLITZ J; WALDENSTROM A; WEDEL H;
Indirizzi:
KAROLINSKA HOSP,DEPT CARDIOL S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT MED S-17176 STOCKHOLM SWEDEN SAHLGRENS UNIV HOSP,DEPT MED GOTHENBURG SWEDEN NORRLAND UNIV HOSP,DEPT MED UMEA SWEDEN NORD SCH PUBL HLTH GOTHENBURG SWEDEN
Titolo Testata:
Cardiovascular Research
fascicolo: 1, volume: 34, anno: 1997,
pagine: 248 - 253
SICI:
0008-6363(1997)34:1<248:MPIDWM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-GLUCOSE INFUSION; BETA-BLOCKERS; SHORT-TERM; HYPERGLYCEMIA; HEART; PROGNOSIS; MELLITUS; DETERMINANTS; FEASIBILITY; METOPROLOL;
Keywords:
MYOCARDIAL INFARCTION; DIABETES; MORTALITY; MORBIDITY; PREDICTION; BETA-BLOCKERS; INSULIN; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K. Malmberg et al., "MORTALITY PREDICTION IN DIABETIC-PATIENTS WITH MYOCARDIAL-INFARCTION - EXPERIENCES FROM THE DIGAMI STUDY", Cardiovascular Research, 34(1), 1997, pp. 248-253

Abstract

Objectives: We analysed predictors of 1-year mortality following acute myocardial infarction in patients with diabetes mellitus by applyinguni- and multivariate statistics on the DIGAMI cohort. Background: Diabetic patients with acute myocardial infarction have a poor prognosis, This may depend on a poor metabolic control, a hypothesis that was tested in DIGAMI, a prospective randomised study. In this trial institution of immediate intensive insulin treatment reduced 1-year mortalityby 30%. Methods: We recruited 620 diabetic patients with acute myocardial infarction, 314 of whom served as controls, while the remaining 306 patients were treated with an acute insulin-glucose infusion followed-by multidose subcutaneous insulin. Results: Age, previous myocardial damage, duration of the diabetes and previous insulin therapy were significantly related to 1-year mortality, white conventional risk factors lacked independent prognostic weight, Female sex was not linked tomortality when controlling for the confounding effects of other predictors. One of the strongest predictors of a fatal outcome, in particular during the hospital phase, was blood glucose at hospital admission. Beta-blockade appeared to exert a striking, independent secondary-preventive effect. Conclusions: It seems that good metabolic control and not conventional risk factors is of major importance for diabetic patients sustaining acute myocardial infarction. Also treatment with beta-blockade seems to be of special importance in this category of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:38:05