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Titolo:
The effects of graded doses of endothelin-1 on coronary perfusion pressureand vital organ blood flow during cardiac arrest
Autore:
DeBehnke, D;
Indirizzi:
Med Coll Wisconsin, Dept Emergency Med, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 cy Med, Milwaukee, WI 53226 USA
Titolo Testata:
ACADEMIC EMERGENCY MEDICINE
fascicolo: 3, volume: 7, anno: 2000,
pagine: 211 - 221
SICI:
1069-6563(200003)7:3<211:TEOGDO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CARDIOPULMONARY-RESUSCITATION; VASOCONSTRICTOR PEPTIDE; RECEPTORS; EPINEPHRINE; POTENT; ANTAGONIST; VESSELS; BQ-788; CELLS; ET(A);
Keywords:
endothelin; cardiopulmonary resuscitation; blood flow; cardiac arrest; coronary perfusion pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: DeBehnke, D Med Coll Wisconsin, Dept Emergency Med, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA Med Coll Wisconsin 9200 W Wisconsin Ave Milwaukee WI USA 53226
Citazione:
D. DeBehnke, "The effects of graded doses of endothelin-1 on coronary perfusion pressureand vital organ blood flow during cardiac arrest", ACAD EM MED, 7(3), 2000, pp. 211-221

Abstract

Background: Endothelin-l (ET-1) is a potent vasoconstrictor and has been shown to improve coronary perfusion pressure (CPP) during arrest. The effects of ET-1 on organ blood flow during arrest have not been extensively studied. Objective: To investigate the effects of ET-1 on myocardial and cerebral blood flow during cardiac arrest. Methods: Sixty immature swine were anesthetized and instrumented. The animals were randomized to receive one of three doses of ET-1 (50, 150, or 300 mu g) or placebo with/without standard-dose epinephrine (SDE) during cardiac arrest. After a 10-minute period of no-flow ventricular fibrillation (VF), cardiopulmonary resuscitation (CPR) was performed for 3 minutes, followed by drug administration. Placebo or SDE was given every 3 minutes. Myocardial and cerebral blood flow was measured using a fluorescent microsphere technique. Results: Prearrest and CPR variables were not different between groups. Beginning 4 minutes after giving 300 mu g ET-1 with or without SDE, CPP was significantly increased compared with SDE alone. Total myocardial blood flow following ET-1 administration was no different than myocardial blood flow following SDE alone. Cerebral blood flow increased 3.5 minutes after administration of 300 mu g ET-1 with SDE and reached significance 9.5 minutes after drug administration when compared with SDE alone [92.5 (48.8-117.9) vs 15.6 (7.7-23) mL/min/100 g]. Conclusions: Three hundred mu g ET-1 with SDE increases CPP and improves cerebral blood flow but does not improve myocardial blood flow during cardiac arrest. The peripheral effects of ET-1 significantly improve CPP and cerebral blood flow, but myocardial blood flow is not increased due to coronary vasoconstriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:40:48