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Titolo:
Extent of extracapsular extension in localized prostate cancer
Autore:
Sohayda, C; Kupelian, PA; Levin, HS; Klein, EA;
Indirizzi:
Cleveland Clin Fdn, Dept Radiat Oncol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Oncol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Urol, Cleveland, OH 44195 USA Cleveland Clin FdnCleveland OH USA 44195 t Urol, Cleveland, OH 44195 USA
Titolo Testata:
UROLOGY
fascicolo: 3, volume: 55, anno: 2000,
pagine: 382 - 386
SICI:
0090-4295(200003)55:3<382:EOEEIL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADICAL PROSTATECTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
2
Recensione:
Indirizzi per estratti:
Indirizzo: Kupelian, PA Cleveland Clin Fdn, Dept Radiat Oncol, Desk T28,9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn Desk T28,9500 Euclid Ave Cleveland OH USA 44195
Citazione:
C. Sohayda et al., "Extent of extracapsular extension in localized prostate cancer", UROLOGY, 55(3), 2000, pp. 382-386

Abstract

Objectives. To measure the radial extent of extracapsular penetration by tumor cells, thereby providing estimates of the margins needed around targetvolumes. New radiotherapeutic techniques, like brachytherapy and conformalradiotherapy, irradiate small Volumes and reduce the dose to periprostatictissues. Even in the early stages of localized prostate cancer, extracapsular extension (ECE) is commonly seen. Methods. Two hundred sixty-five consecutive radical prostatectomy specimens were analyzed for the presence of ECE. ECE was found in 92 of all cases (35%); measurements were performed in 79 of the 92 cases. A total of 98 ECE sites were evaluated in the 79 cases. The distance of tumor outside the capsule was measured in millimeters. Extension less than 0.1 mm was consideredas "focal. "Results. The site of ECE was posterolateral in 53% of cases, lateral in 24%, posterior in 13%, and at the base in 10%. The median amount of ECE at all sites was 1.1 mm (mean 1.7). However, the range was wide; the minimum measurable extent was 0.1 mm and the maximum 10.0 mm. The extent was within 3.8 mm for 90% of all cases. By stratifying cases with favorable and unfavorable tumors, the 90th percentiles of ECE were as follows: 3.3 mm for favorable tumors (clinical Stage Tl-2, initial prostate-specific antigen 10 ng/mL or less, and biopsy Gleason score 6 or less) and 3.9 mm for unfavorable tumors (clinical Stage T3, initial prostate-specific antigen greater than 10 ng/mL, or biopsy Gleason score 7 or greater). Conclusions. Most of the ECE was at posterolateral sites. The extent of disease outside the prostate was within 4 mm in 90% of cases. Since ECE was observed in 30% to 60% of all patients with clinical Stage Tl-2 prostate cancer, only 3% to 7% of all such cases would have disease extent exceeding 4 mm. The present study provides useful estimates of the amount of ECE. Theseestimates could be potentially used in planning the target volumes for treatment of prostate cancer with either conformal radiotherapy or brachytherapy, (C) 2000, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:28:06