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Titolo:
Combined intravesical and oral oxybutynin chloride in adult patients with spinal cord injury
Autore:
Pannek, J; Sommerfeld, HJ; Botel, U; Senge, T;
Indirizzi:
Ruhr Univ Bochum, Dept Urol, D-4690 Herne, Germany Ruhr Univ Bochum Herne Germany D-4690 , Dept Urol, D-4690 Herne, Germany Ruhr Univ Bochum, Dept Surg, D-4690 Herne, Germany Ruhr Univ Bochum Herne Germany D-4690 , Dept Surg, D-4690 Herne, Germany
Titolo Testata:
UROLOGY
fascicolo: 3, volume: 55, anno: 2000,
pagine: 358 - 362
SICI:
0090-4295(200003)55:3<358:CIAOOC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROGENIC BLADDER DYSFUNCTION; DETRUSOR HYPERREFLEXIA; FOLLOW-UP; CHILDREN; INSTILLATION; HYPERACTIVITY; RELAXATION; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Pannek, J Ruhr Univ Bochum, Urol Klin, Marien Hosp Herne, Widumer Str 8, D-44627 Herne, Germany Ruhr Univ Bochum Widumer Str 8 Herne Germany D-44627e, Germany
Citazione:
J. Pannek et al., "Combined intravesical and oral oxybutynin chloride in adult patients with spinal cord injury", UROLOGY, 55(3), 2000, pp. 358-362

Abstract

Objectives. Detrusor hyperreflexia with elevated storage pressures presents a major risk factor for renal damage in patients with neurogenic lower urinary tract dysfunction. If standard anticholinergic treatment is unsuccessful, surgical treatment must be considered. We evaluated the effects of intravesical oxybutynin treatment an detrusor hyperreflexia in patients in whom standard oral treatment had failed. Methods. Twenty-five patients (mean age 36.7 years) with storage pressuresgreater than 40 cm H2O despite standard anticholinergic treatment receivedintravesical (15 mg three times daily) and oral oxybutynin chloride treatment. The follow-up evaluations included urodynamic testing, renal ultrasound, urine examination (urinalysis and urine culture), and evaluation of sideeffects. Results. The mean follow-up was 6 months. Intravesical treatment led to anincrease in bladder storage volume from 349 to 420 mt. The mean maximum storage pressure was significantly reduced from 54 to 26.5 cm H2O. Detrusor storage pressures returned to values less than 40 cm H2O in 21 of 25 patients. Dysreflexia was treated successfully in 3 of 5 patients. No patient developed renal damage. No severe side effects or drug-related discontinuation of treatment were observed. Conclusions. Intravesical oxybutynin therapy seems to be a safe and effective treatment option for detrusor hyperreflexia in adults and avoids surgical treatment in most patients. Long-term observations concerning side effects, acceptance, and efficacy are needed. (C) 2000, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:11:02