Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Stiffness of carotid artery wall material and blood pressure in humans - Application to antihypertensive therapy and stroke prevention
Autore:
Safar, ME; Blacher, J; Mourad, JJ; London, GM;
Indirizzi:
Hop Broussais, Dept Internal Med, F-75674 Paris 14, France Hop Broussais Paris France 14 ept Internal Med, F-75674 Paris 14, France Hop Broussais, INSERM U337, F-75674 Paris, France Hop Broussais Paris France F-75674 s, INSERM U337, F-75674 Paris, France Manhes Ctr, Dept Nephrol, Fleury Merogis, France Manhes Ctr Fleury Merogis France , Dept Nephrol, Fleury Merogis, France
Titolo Testata:
STROKE
fascicolo: 3, volume: 31, anno: 2000,
pagine: 782 - 790
SICI:
0039-2499(200003)31:3<782:SOCAWM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE RENAL-DISEASE; SPONTANEOUSLY HYPERTENSIVE RATS; CONVERTING-ENZYME-INHIBITION; ISOLATED SYSTOLIC HYPERTENSION; MECHANICAL-PROPERTIES; PULSE PRESSURE; ANGIOTENSIN-II; NITRIC-OXIDE; IN-VIVO; CARDIOVASCULAR MORTALITY;
Keywords:
arterial wall; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Safar, ME Hop Broussais, Dept Internal Med, 96 Rue Didot, F-75674 Paris 14, France Hop Broussais 96 Rue Didot Paris France 14 674 Paris 14, France
Citazione:
M.E. Safar et al., "Stiffness of carotid artery wall material and blood pressure in humans - Application to antihypertensive therapy and stroke prevention", STROKE, 31(3), 2000, pp. 782-790

Abstract

Background and Purpose-Because epidemiological studies show that increasedpulse pressure and carotid wall-material stiffness are predictors of cardiovascular mortality independent of age, atherosclerosis, and conventional risk factors, the relationships between carotid wall stiffness and blood pressure are important to the optimization of cardiovascular prevention. Summary of Review-In middle-aged hypertensive patients, mean and pulse pressures are increased, and systolic and diastolic pressures are increased tothe same degree as mean pressure. Carotid hypertrophy is associated with normal wall stress, but no increased stiffness of wall material has been reported. With age, the normal wall stress is associated with a larger diameter and a stiffer material of carotid but not peripheral arteries. The stiffer wall involves calcifications, large amounts of collagen, and fragmentation and rupture of elastic tissue, which results in increased pulse-wave velocity and alterations of amplitude and timing of wave reflections and thus causes a disproportionate increase in systolic and pulse pressure. During this period, acutely administered nitrates in elderly subjects are able to reduce selectively systolic and pulse pressures without altering diastolic and mean blood pressure and composition of the carotid wall. Conclusions-New therapeutic approaches acting mainly on the wall of large arteries are needed to treat hypertension in elderly patients and prevent stroke and myocardial infarction. These drugs could either selectively lowerpulse pressure through changes in wave reflections (as nitrates do) or decrease arterial wall stiffness through modification of the composition of material (such as compounds that act on collagen cross-linking).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:00:56