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Titolo:
Immunity against extracellular pathogens
Autore:
Gatfield, J; Ferrari, G; Pieters, J;
Indirizzi:
Basel Inst Immunol, CH-4005 Basel, Switzerland Basel Inst Immunol Basel Switzerland CH-4005 CH-4005 Basel, Switzerland
Titolo Testata:
PROTOPLASMA
fascicolo: 3-4, volume: 210, anno: 2000,
pagine: 99 - 107
SICI:
0033-183X(2000)210:3-4<99:IAEP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II MOLECULES; MAJOR HISTOCOMPATIBILITY COMPLEX; MHC CLASS-I; INVARIANT CHAIN CONTAINS; ANTIGEN PRESENTATION; MAMMALIAN-CELLS; INNATE IMMUNITY; INTRACELLULAR-TRANSPORT; BACTERIAL PATHOGENS; ENDOCYTIC PATHWAY;
Keywords:
antigen processing; antigen presentation; phagocytosis; host defense subversion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Pieters, J Basel Inst Immunol, Grenzacherstr 487, CH-4005 Basel, Switzerland Basel Inst Immunol Grenzacherstr 487 Basel Switzerland CH-4005
Citazione:
J. Gatfield et al., "Immunity against extracellular pathogens", PROTOPLASMA, 210(3-4), 2000, pp. 99-107

Abstract

Eukaryotic cells live in a relatively comfortable equilibrium with a wide variety of microbes. However, while many of the cohabiting microorganisms are harmless or even beneficial to the eukaryotic host, a number of prokaryotes have evolved the capacity to invade and replicate within host cells, thereby becoming potentially pathogenic. To be able to cope with potential pathogens, most organisms have developed several host defense mechanisms. First. microbes can be internalized and destroyed by a number of cell types ofan innate immune system in a rather aspecific manner. Second, more complexorganisms possess additionally an adaptive immune system that is capable of eliminating hazardous microbes in a highly specific manner. This review describes recent progress in our understanding of how pathogens interact with cells of the immune system, resulting in activation of the immune system or, for certain microorganisms, in the evasion of host defense reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:46:47