Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association study of dopamine receptor gene polymorphisms with drug-induced hallucinations in patients with idiopathic Parkinson's disease
Autore:
Makoff, AJ; Graham, JM; Arranz, MJ; Forsyth, J; Li, T; Aitchison, KJ; Shaikh, S; Grunewald, RA;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Univ Sheffield, Royal Hallamshire Hosp, Sect Clin Neurol, Sheffield S10 2JF, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2JF S Yorkshire, England
Titolo Testata:
PHARMACOGENETICS
fascicolo: 1, volume: 10, anno: 2000,
pagine: 43 - 48
SICI:
0960-314X(200002)10:1<43:ASODRG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
D3 RECEPTOR; SCHIZOPHRENIA; NEUROLEPTICS; CLOZAPINE; DIAGNOSIS; AGONISTS; BRAIN;
Keywords:
DRD2; DRD3; adverse effects; psychosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Makoff, AJ Inst Psychiat, Dept Psychol Med, Denmark Hill, London SE5 8AF, England Inst Psychiat Denmark Hill London England SE5 8AF 8AF, England
Citazione:
A.J. Makoff et al., "Association study of dopamine receptor gene polymorphisms with drug-induced hallucinations in patients with idiopathic Parkinson's disease", PHARMACOGEN, 10(1), 2000, pp. 43-48

Abstract

Some patients with idiopathic Parkinson's disease experience hallucinations as a result of treatment with levodopa and dopamine agonists, There is evidence for some heterogeneity in these hallucinating patients based on duration of Parkinson's disease at onset of hallucinations, We compared the frequency of polymorphisms in the dopamine D-2 and D-3 receptor genes between patients with drug-induced hallucinations and non-hallucinating patients. Two polymorphisms close to DRD2 and one in DRD3 were studied. No associationwas found with the whole group of hallucinating patients and their controls. However, an association was found with late-onset hallucinations and theC allele of the TaqIA polymorphism, 10.5 kb 3' to DRD2, This polymorphism may be in linkage disequilibrium with a mutation in DRD2 or a nearby gene that predisposes to drug-induced hallucinations which occur later in the course of idiopathic Parkinson's disease. Pharmacogenetics 10:43-48 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:07:52