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Titolo:
Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
Autore:
Kuhajda, FP;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 Pathol, Baltimore, MD 21224 USA
Titolo Testata:
NUTRITION
fascicolo: 3, volume: 16, anno: 2000,
pagine: 202 - 208
SICI:
0899-9007(200003)16:3<202:FSAHCN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL OVARIAN-CANCER; ACETYL-COA CARBOXYLASE; CELL-LINE LNCAP; BREAST-CANCER; DIETARY-FAT; HORMONAL-REGULATION; GENE-TRANSCRIPTION; ENERGY-METABOLISM; PROSTATE-CANCER; ADIPOSE-TISSUE;
Keywords:
fatty-acid synthase; fatty-acid synthesis; cancer; cerulenin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhajda, FP Johns Hopkins Univ, Sch Med, Dept Pathol, Johns Hopkins Bayview,4940 Eastern Ave,Bldg AA, Baltimore, MD 21224 USA Johns Hopkins Univ Johns Hopkins Bayview,4940 Eastern Ave,Bldg AA Baltimore MD USA 21224
Citazione:
F.P. Kuhajda, "Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology", NUTRITION, 16(3), 2000, pp. 202-208

Abstract

This review documents the changing perspectives on the function of fatty-acid synthase and fatty-acid synthesis in human tumor biology. With the recent discovery that human cancer cells express high levels of fatty-acid synthase and undergo significant endogenous fatty-acid synthesis, our understanding of the role of fatty acids in tumor biology is expanding. Once considered largely an anabolic-energy-storage pathway, fatty-acid synthesis is nowassociated with clinically aggressive tumor behavior and tumor-cell growthand survival and has become a novel target pathway for chemotherapy development. These findings will ultimately enhance our understanding of fatty acids in tumor biology and may provide new diagnostic and therapeutic moieties for patient care. (C) Elsevier Science Inc. 2000.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:34:37