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Titolo:
Muscarinic receptors depress gabaergic synaptic transmission in rat midbrain dopamine neurons
Autore:
Grillner, P; Berretta, N; Bernardi, G; Svensson, TH; Mercuri, NB;
Indirizzi:
IRCCS, Clin S Lucia, I-00179 Rome, Italy IRCCS Rome Italy I-00179IRCCS, Clin S Lucia, I-00179 Rome, Italy Karolinska Inst, Div Neuropsychopharmacol, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 acol, S-17177 Stockholm, Sweden Univ Roma Tor Vergata, I-00173 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00173 or Vergata, I-00173 Rome, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 96, anno: 2000,
pagine: 299 - 307
SICI:
0306-4522(2000)96:2<299:MRDGST>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; RETICULATA PROJECTION NEURONS; SUBUNIT MESSENGER-RNA; SUBSTANTIA-NIGRA; ACETYLCHOLINE-RECEPTORS; CHOLINERGIC STIMULATION; BASAL GANGLIA; IN-VITRO; BRAIN; INVITRO;
Keywords:
acetylcholine; muscarine; nicotine; inhibitory postsynaptic potentials; miniature inhibitory postsynaptic currents; presynaptic inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Mercuri, NB IRCCS, Clin S Lucia, Via Ardeatina 306, I-00179 Rome, Italy IRCCS Via Ardeatina 306 Rome Italy I-00179 -00179 Rome, Italy
Citazione:
P. Grillner et al., "Muscarinic receptors depress gabaergic synaptic transmission in rat midbrain dopamine neurons", NEUROSCIENC, 96(2), 2000, pp. 299-307

Abstract

The effects of muscarine and nicotine on evoked and spontaneous release ofGABA were studied using intracellular and whole-cell patch-clamp recordings from rat midbrain dopamine neurons in an in vitro slice preparation. Muscarine (30 mu M) reversibly depressed the pharmacologically isolated inhibitory postsynaptic potential evoked by local electrical stimulation. The maximal inhibition of the inhibitory postsynaptic potential amplitude was 39.6 /- 5%. This depressant effect of muscarine was blocked by the M3/M1 receptor antagonist 3-diphenylacetoxy-N-methylpiperidine methiodide (100 nM), butwas slightly affected by the M1/M3 receptor antagonist pirenzepine (1 mu M). In addition, muscarine decreased the frequency of the miniature synapticcurrents without any effect on their amplitude. Moreover, muscarine did not change the GABA-induced hyperpolarization, indicating that its effect on the inhibitory postsynaptic potential is mediated by presynaptic receptors. On the contrary, the cholinergic agonist nicotine did not change the frequency or the amplitude of the spontaneous glutamatergic and GABAergic synaptic currents. Our data indicate that a prevalent activation of presynaptic M3 muscarinicreceptors inhibits the GABA-mediated synaptic events, while the activationof nicotinic receptors does not affect the release of glutamate and GABA on midbrain dopamine neurons. (C) 2000 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:46:03