Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Conditioned alterations of specific blood leukocyte subsets are reconditionable
Autore:
Exton, MS; von Horsten, S; Strubel, T; Donath, S; Schedlowski, M; Westermann, J;
Indirizzi:
Univ Essen Gesamthsch, Fac Med, Inst Med Psychol, D-45122 Essen, Germany Univ Essen Gesamthsch Essen Germany D-45122 chol, D-45122 Essen, Germany Hannover Med Sch, Dept Funct & Appl Anat, D-3000 Hannover, Germany Hannover Med Sch Hannover Germany D-3000 Anat, D-3000 Hannover, Germany
Titolo Testata:
NEUROIMMUNOMODULATION
fascicolo: 2, volume: 7, anno: 2000,
pagine: 106 - 114
SICI:
1021-7401(2000)7:2<106:CAOSBL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLER-CELL-ACTIVITY; LYMPHOCYTE SUBSETS; TASTE-AVERSION; CYCLOSPORINE-A; HOST RESPONSE; IMMUNE-SYSTEM; RATS; SUPPRESSION; MIGRATION; HEART;
Keywords:
classical conditioning; cyclosporin A; lymphocyte subsets; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Exton, MS Univ Essen Gesamthsch Klinikum, Inst Med Psychol, Hufelandstr 55, D-45122 Essen, Germany Univ Essen Gesamthsch Klinikum Hufelandstr 55 Essen Germany D-45122
Citazione:
M.S. Exton et al., "Conditioned alterations of specific blood leukocyte subsets are reconditionable", NEUROIMMUNO, 7(2), 2000, pp. 106-114

Abstract

Behavioral conditioning has the ability to produce changes in immune function. However, it is unknown whether conditioned changes of immune function can be recalled on multiple occasions, To address this issue we paired a novel saccharin drinking solution with intraperitoneal cyclosporin A (CsA) injection in rats. Saccharin representation produced a reduction in splenocyte proliferation that mirrored the effect of CsA. Such functional changes were paralleled by a significant conditioned leukopenia in peripheral blood, which opposed the leukocytosis induced by CsA. Using the conditioned leukopenia in blood as a 'diagnostic window' of conditioned immunosuppression, the maintenance of CsA-induced changes was investigated by examining blood samples collected repeatedly. Experiments on the same group of animals over aperiod of 1 year showed that the conditioned leukopenia was reproducible on multiple occasions by reimplementing either the whole conditioning paradigm or reexposure to the saccharin solution only. These results demonstrate that behaviorally conditioned alterations of immune parameters are maintained in subsequent trials, indicating the potential clinical feasibility of behavioral conditioning procedures. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 11:52:24