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Titolo:
Expression of HLA-DR and its enhancing molecules in muscle fibers in polymyositis
Autore:
Inukai, A; Kuru, S; Liang, YD; Takano, A; Kobayashi, Y; Sakai, M; Doyu, M; Sobue, G;
Indirizzi:
Nagoya Univ, Sch Med, Dept Neurol, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Suzuka Natl Sanatorium, Dept Neurol, Suzuka 5138501, Japan Suzuka Natl Sanatorium Suzuka Japan 5138501 eurol, Suzuka 5138501, Japan
Titolo Testata:
MUSCLE & NERVE
fascicolo: 3, volume: 23, anno: 2000,
pagine: 385 - 392
SICI:
0148-639X(200003)23:3<385:EOHAIE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II MOLECULES; ANTIGEN-PROCESSING MUTANT; POLYMERASE CHAIN-REACTION; BARE LYMPHOCYTE SYNDROME; INVARIANT CHAIN; INTERFERON-GAMMA; HUMAN MYOBLASTS; MHC MOLECULES; INFLAMMATORY MYOPATHY; TRANSACTIVATOR CIITA;
Keywords:
antigen presentation; class II transactivator; HLA-DM; HLA-DR; invariant chain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Sobue, G Nagoya Univ, Sch Med, Dept Neurol, Showa Ku, 65 Tsurumai-cho, Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsurumai-cho Nagoya Aichi Japan 4668550 550, Japan
Citazione:
A. Inukai et al., "Expression of HLA-DR and its enhancing molecules in muscle fibers in polymyositis", MUSCLE NERV, 23(3), 2000, pp. 385-392

Abstract

Polymyositis (PM) is an autoimmune inflammatory muscle disease of unknown cause in which cellular immunity is thought to play an important pathogenicrole. Class II major histocompatibility complex (class II MHC: human leukocyte antigen (HLA)-DR operates as a cofactor of antigen presentation in immunological responses. There has been a major debate over whether muscle fibers themselves synthesize and express HLA-DR molecules and play a role in antigen presentation in PM pathogenesis. In this study, we demonstrated thatmost muscle fibers from patients with PM synthesized and expressed HLA-DR molecules on their surface. Human leukocyte antigen-DR expression was highly specific to PM. In addition, class II transactivator (CIITA), human leukocyte antigen DM (HLA-DM), and invariant chain (li), which are indispensablefor expression of mature HLA-DR molecules and for antigen processing and presentation, were co-expressed. One of the cytokines that could induce thisexpression is interferon-gamma (IFN-gamma), released by activated lymphocytes. Our results indicate that in PM muscle fibers synthesize and express HLA-DR molecules and may contribute to the inflammatory responses together with lymphocytes. (C) 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 385-392,2000.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:32:05