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Titolo:
Expression of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type IA receptor mRNAs in granulosa cells of preovulatory follicles of the rat ovary
Autore:
Koh, PO; Kwak, SD; Kang, SS; Cho, GJ; Chun, SY; Kwon, HB; Choi, WS;
Indirizzi:
Gyeongsang Natl Univ, Coll Med, Dept Anat, Chinju 660751, Kyungnam, South Korea Gyeongsang Natl Univ Chinju Kyungnam South Korea 660751 gnam, South Korea Gyeongsang Natl Univ, Coll Vet Med, Dept Histol, Chinju 660751, Kyungnam, South Korea Gyeongsang Natl Univ Chinju Kyungnam South Korea 660751 gnam, South Korea Chunnam Natl Univ, Hormone Res Ctr, Kwangju, South Korea Chunnam Natl Univ Kwangju South Korea one Res Ctr, Kwangju, South Korea
Titolo Testata:
MOLECULAR REPRODUCTION AND DEVELOPMENT
fascicolo: 4, volume: 55, anno: 2000,
pagine: 379 - 386
SICI:
1040-452X(200004)55:4<379:EOPACA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE DISTRIBUTION; MESSENGER-RNA; INTESTINAL POLYPEPTIDE; PROGESTERONE-RECEPTOR; HORMONAL-REGULATION; IN-VITRO; LOCALIZATION; OVULATION; PEPTIDE; STEROIDOGENESIS;
Keywords:
PACAP; receptor; granulosa cell; ovary; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Choi, WS Gyeongsang Natl Univ, Coll Med, Dept Anat, Chinju 660751, Kyungnam, South Korea Gyeongsang Natl Univ Chinju Kyungnam South Korea 660751 th Korea
Citazione:
P.O. Koh et al., "Expression of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type IA receptor mRNAs in granulosa cells of preovulatory follicles of the rat ovary", MOL REPROD, 55(4), 2000, pp. 379-386

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) was isolated from ovine hypothalamus and known to stimulate the production of cAMP in anterior pituitary cells. In the recent report, the expression of PACAP was detected in preovulatory follicles, and treatment with PACAP stimulated the production of progesterone and prostaglandin E-2 through the action of AC andPLC pathways in the ovary. PACAP binds to three type receptors. Type I A receptor is coupled to adenylate cyclase (AC) and phospholipase C (PLC) pathways, while type I B and type II receptors are only coupled to AC. Thus, the present study aimed to evaluate the temporal expression of PACAP and its type I A receptor mRNAs in the rat ovary after treatment with pregnant mare's serum gonadotropin and human chorionic gonadotropin (hCG). Northern blot analysis showed that PACAP transcripts were transiently expressed from 3-9 hr after hCG treatment, reaching a maximum at 6 hr. During these time points, PACAP mRNAs were specifically and strongly expressed in granulosa cells and cumulus cells of large preovulatory follicles and interstitial glandular cells. Type I A receptor mRNAs were also transiently expressed in granulosa cells of large preovulatory follicles from 3-9 hr after hCG treatment. PACAP and its type I A receptor mRNAs were expressed in the same preovulatory follicles. These results demonstrate that PACAP acts as anautoregulator or pararegulator through type I A receptor in granulosa cells and cumulus cells of large preovulatory follicles. Thus, we suggest that PACAP may have a critical role in granulosa cells of preovulatory folliclesfor the preparation of ovulation. Mol. Reprod. Dev. 55:379-386, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:49:10