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Titolo:
In vivo NMDA/dopamine interaction resulting in Fos production in the limbic system and basal ganglia of the mouse brain
Autore:
Radulovic, J; Blank, T; Nijholt, I; Kammermeier, J; Spiess, J;
Indirizzi:
Max Planck Inst Expt Med, Dept Mol Neuroendocrinol, D-37075 Gottingen, Germany Max Planck Inst Expt Med Gottingen Germany D-37075 75 Gottingen, Germany
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 2, volume: 75, anno: 2000,
pagine: 271 - 280
SICI:
0169-328X(20000222)75:2<271:IVNIRI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONIST SKF-82958; EARLY GENE-EXPRESSION; RAT STRIATAL NEURONS; D1 DOPAMINE RECEPTOR; C-FOS; MESSENGER-RNA; PARKINSONS-DISEASE; NMDA RECEPTORS; STRIATOPALLIDAL NEURONS; DEPENDENT POTENTIATION;
Keywords:
immediate early gene; hippocampus; amygdala; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Spiess, J Max Planck Inst Expt Med, Dept Mol Neuroendocrinol, Hermann ReinStr 3, D-37075 Gottingen, Germany Max Planck Inst Expt Med Hermann Rein Str 3 Gottingen Germany D-37075
Citazione:
J. Radulovic et al., "In vivo NMDA/dopamine interaction resulting in Fos production in the limbic system and basal ganglia of the mouse brain", MOL BRAIN R, 75(2), 2000, pp. 271-280

Abstract

Glutamatergic and dopaminergic Glutamatergic and dopaminergic effects on molecular processes have been extensively investigated in the basal ganglia. It has been demonstrated that NMDA and dopamine D-1 and D-2 receptors interact in the regulation of signal transduction and induction of transcription factors. In the present experiments, NMDA/dopamine interactions were investigated in the normosensitive caudate nucleus, hippocampus and amygdala bymonitoring Fos production. We demonstrated that NMDA and the D-1 receptor agonist SKF 38393 triggered Fos levels in a distinct, non-overlapping and region-specific pattern. NMDA injected intraperitoneally (i.p.) elevated Foslevels in all hippocampal subfields and the central amygdala, whereas SKF 38393 triggered Fos production in basomedial, cortical, medial amygdala andcaudate nucleus. The NMDA receptor antagonist CGS 19755 prevented NMDA- and SKF 38393-triggered Fos production in all investigated brain areas. Similarly, the D-1 receptor antagonist SCH 23390 inhibited the effects produced by SKF 38393 or NMDA. The D-2 receptor antagonist sulpiride exerted synergistic and antagonistic effects on NMDA- and SKF 38393-triggered Fos production, in a region specific manner. These data suggest that NMDA and dopamine receptors regulate Fos production within I-he limbic system and basal,ganglia through regionally differentiated but interdependent actions. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:14:00