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Titolo:
Time-dependent changes in dopamine D-2-receptor mRNA in the arterial chemoreflex pathway with chronic hypoxia
Autore:
Huey, KA; Powell, FL;
Indirizzi:
Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 2, volume: 75, anno: 2000,
pagine: 264 - 270
SICI:
0169-328X(20000222)75:2<264:TCIDDM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAROTID-BODY CHEMORECEPTORS; RECEPTOR MESSENGER-RNA; VENTILATORY ACCLIMATIZATION; D2-DOPAMINE RECEPTOR; BRAIN-STEM; RATS; EXPRESSION; TRANSPORTER; METABOLISM; ALTITUDE;
Keywords:
chronic hypoxia; dopamine D-2-receptor; nucleus tractus solitarius; carotid body; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Huey, KA Univ Calif Irvine, Irvine 346-D Med Sci 1, Irvine, CA 92697 USA Univ Calif Irvine Irvine 346-D Med Sci 1 Irvine CA USA 92697 USA
Citazione:
K.A. Huey e F.L. Powell, "Time-dependent changes in dopamine D-2-receptor mRNA in the arterial chemoreflex pathway with chronic hypoxia", MOL BRAIN R, 75(2), 2000, pp. 264-270

Abstract

The hypoxic ventilatory response (HVR) can be modulated by dopamine D-2-receptors (D-2-R) in both the carotid body arterial chemoreceptors and the nucleus tractus solitarius (NTS), the primary synapse site of carotid body afferents. We hypothesized that chronic hypoxia alters D-2-R gene expression to initiate changes in D-2-R modulation of the HVR and enhance ventilatory acclimatization to hypoxia. Thus, we used a competitive reverse transcription-polymerase chain reaction (RT-PCR) method ru quantify changes in D-2-R mRNA levels in the rat carotid body and NTS after 0, 6, 12, 24, 38, or 168 hof hypobaric hypoxia (P-IO2 = 80 Torr). In the rostral NTS, hypoxia significantly increased D-2-R mRNA at all time points. In the caudal NTS, D2-R mRNA levels initially increased in response to hypoxia and then significantlydecreased to 71 +/- 5% and 71 +/- 6% of control after 38 and 168 h of hypoxia, respectively. in the carotid body, D-2-R mRNA levels significantly decreased to 59 +/- 2% of control after 38 h of hypoxia; however, they significantly increased to 274 +/- 22% of control after 168 h. These results suggest that changes in D-2-R mRNA in the arterial chemoreflex pathway and corresponding changes at the protein and signaling levels may contribute to the time-dependent changes in ventilation observed with chronic hypoxia. Specifically, decreased carotid body inhibition by D-2-R could increase the HVR after 2 days of hypoxia. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/01/20 alle ore 12:53:47