Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inguinal hernia in patients with Ewing sarcoma: A clue to etiology
Autore:
Cope, JU; Tsokos, M; Helman, LJ; Gridley, G; Tucker, MA;
Indirizzi:
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Canc Epidemiol & Genet, Bethesda, MD 20892 USA NCI, Dept Pathol, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Dept Pathol, Bethesda, MD 20892 USA NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 CI, Pediat Oncol Branch, Bethesda, MD 20892 USA
Titolo Testata:
MEDICAL AND PEDIATRIC ONCOLOGY
fascicolo: 3, volume: 34, anno: 2000,
pagine: 195 - 199
SICI:
0098-1532(200003)34:3<195:IHIPWE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOFT-TISSUE SARCOMAS; TESTICULAR DESCENT; CHILDHOOD-CANCER; BONE; CRYPTORCHIDISM; CHILDREN; RISK;
Keywords:
inguinal hernia; Ewing sarcoma; etiology; congenital anomaly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Cope, JU NCI, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS Room 7007, Bethesda,MD 20892 USA NCI 6120 Execut Blvd,EPS Room 7007 Bethesda MD USA 20892 0892 USA
Citazione:
J.U. Cope et al., "Inguinal hernia in patients with Ewing sarcoma: A clue to etiology", MED PED ONC, 34(3), 2000, pp. 195-199

Abstract

Background. Various congenital anomalies have been associated with childhood cancer, but as yet no anomaly has been consistently found with Ewing sarcoma (ES). Recently a large case-control study of ES patients reported a greater number of hernias in both cases and their sibling controls than in population controls. Most of these hernias were inguinal. Because these anomalies were also reported previously in two case series, we looked for inguinal hernias in a different population of ES patients. Procedure. We abstracted medical records for 306 pathologically confirmed ES/primitive neuroectodermal tumor (PNET) patients seen at NIH between 1960 and 1992. Epidemiological data on demographics and medical conditions were analyzed. The frequency of anomalies was compared to expected rates to calculate relative risk and confidence intervals. Results. Anomalies were present in 67 (22%) cases. A particular anomaly, inguinal hernia, was reported for 13 (5%) NIH cases. Compared to population estimates for white children, the relative risk of inguinal hernia among white NIH cases was 13.3 (95% CI 3.60-34.1) for females and 6.67 (95% Cl 2.67-13.7) for males. Conclusions. The findings of inguinal hernias in some patients with ES suggest that a disruption in normal embryological development occurred. This may provide an important clue to theetiology of ES. We hypothesize that these hernias may relate to an in utero exposure or indicate an underlying genetic disorder. Future studies should carefully evaluate ES families for genetic disease and explore environmental factors. Med. Pediatr. Oncol. 34:195-199, 2000. Published 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:50:27