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Titolo:
Cancer-associated retinopathy - A review article with some clinical examples
Autore:
Sobottka, B; Schlote, T; Besch, D; Djelebova, T; Wilhelm, H; Zrenner, E;
Indirizzi:
Univ Tubingen, Augenklin, Abt Glaskorper & Netzhautchirurg 3, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 rurg 3, D-72076 Tubingen, Germany Univ Tubingen, Augenklin, Abt Allgemeine Augenheilkunde 1, Poliklin, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 liklin, D-72076 Tubingen, Germany Univ Tubingen, Augenklin, Abt Pathophysiol Sehens & Neuroophthalmol 2, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 lmol 2, D-72076 Tubingen, Germany
Titolo Testata:
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
fascicolo: 1, volume: 216, anno: 2000,
pagine: 17 - 24
SICI:
0023-2165(200001)216:1<17:CR-ARA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
GER
Soggetto:
SMALL-CELL-CARCINOMA; PARA-NEOPLASTIC SYNDROME; PARANEOPLASTIC RETINOPATHY; PHOTORECEPTOR DEGENERATION; OPTIC NEURITIS; BRONCHIAL-CARCINOMA; AUTOIMMUNE BASIS; LUNG-CARCINOMA; AUTOANTIBODIES; RECOVERIN;
Keywords:
paraneoplastic syndrome; cancer-associated retinopathy; paraneoplastic optic neuropathy; mamma carcinoma; carcinoma of the endometrium; paraneoplastic neurological syndromes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Sobottka, B Univ Tubingen, Augenklin, Abt Glaskorper & Netzhautchirurg 3, Schleichstr 12, D-72076 Tubingen, Germany Univ Tubingen Schleichstr 12 Tubingen Germany D-72076 Germany
Citazione:
B. Sobottka et al., "Cancer-associated retinopathy - A review article with some clinical examples", KLIN MONATS, 216(1), 2000, pp. 17-24

Abstract

Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome. In this survey we report about two further patients with CAR, who were referred to the University Eye Hospital of Tuebingen within a few months. The mostcommon primary tumor associated with CAR is small cell carcinoma of the lung. Case reports about rhabdomyosarcoma, carcinoma of the endometrium, prostate and mamma were also described. The exact pathogenesis of CAR is still unknown. Specific autoantibodies were found against the photoreceptor protein recoverin (23-kd retinal CAR antigen). However, this reaction is not present in all patients, and probably other antigens are also involved. Most of the patients experience symptoms of CAR before the primary tumor is detected. Besides glare sensitivity and flashing lights, a rapidly progressive, often asymmetric visual loss may occur. Although paracentral and midperipheral scotomas can be found frequently, visual field defects are often quite heterogeneous. Typically, the responses in the electroretinogram (ERG) are markedly reduced, but normal ERGs were also described. The fundus picture in CAR shows sheathing of the retinal vessels, narrowing of the arterioles and crumbing of the retinal pigment epithelium. The prognosis is poor. Frequently there is progression to bilateral loss of vision within a few months. Treatment of the primary tumor does not seem to alter the ocular prognosis. Systemic corticosteroids may be helpful in some patients. Nevertheless, no proven therapeutic regimen is currently available.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:52:12