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Titolo:
High hemoglobin affinity to oxygen and its relationships with lipid peroxidation during fever
Autore:
Zinchuk, V;
Indirizzi:
Grodno Med Inst, Dept Physiol, Grodno 230015, Byelarus Grodno Med Inst Grodno Byelarus 230015 Physiol, Grodno 230015, Byelarus
Titolo Testata:
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
fascicolo: 4, volume: 55, anno: 1999,
pagine: 301 - 308
SICI:
1138-7548(199912)55:4<301:HHATOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTHERMIA; TEMPERATURE; TRANSPORT; ETHANOL; CURVE;
Keywords:
oxygen hemoglobin affinity; lipid peroxidation; fever; lipopolysaccharide; sodium cyanate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Zinchuk, V Grodno Med Inst, Dept Physiol, Str Gorki 80, Grodno 230015, Byelarus Grodno Med Inst Str Gorki 80 Grodno Byelarus 230015 , Byelarus
Citazione:
V. Zinchuk, "High hemoglobin affinity to oxygen and its relationships with lipid peroxidation during fever", J PHYSIOL B, 55(4), 1999, pp. 301-308

Abstract

The effects of high hemoglobin-oxygen affinity (HOA) on rectal temperatureand lipid free radical oxidation were investigated in red blood cells, heart, liver and kidneys of male rats during fever. Fever was induced by intraperitoneal injection of Salmonella typhi lipopolysaccharide (LPS; 5.0 mg kg(-1)). HOA was increased by addition of 0.5% sodium cyanate to drinking water for eight weeks. HOA modification tactual half-saturation oxygen pressure, P(50)act, decreased to 23.3 +/- 0.7 vs. 31.6 +/- 0.7 Torr in control; p < 0.001) weakened a febrile response: rise of temperature after 4 hours was0.79 +/- 0.2 degrees C vs. 1.38 +/- 0.1 degrees C in rats with normal HOA (p < 0.05). In red cells and tissues of rats with normal HOA, concentrations of conjugated dienes and Schiff bases increased during fever, and a-tocopherol level and catalase activity decreased. Rats with increased HOA had aninverse pattern of such changes. Changes in rectal temperature and markersof free radical oxidation correlated with a shift of oxyhemoglobin dissociation curve leftwards. The present results indicate that the intentional increment of HOA may substantially diminish lipid peroxidation activity, increase the body antioxidant content during fever and decrease the febrile response on LPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:49:18