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Titolo:
Effects of chronic stress on hypothalamic lnterleukin-1 beta, interleukin-2, and gonadotrophin-releasing hormone gene expression in ovariectomized rats
Autore:
Tanebe, K; Nishijo, H; Muraguchi, A; Ono, T;
Indirizzi:
Toyama Med & Pharmaceut Univ, Fac Med, Dept Physiol, Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Sugitani Toyama Japan 9300194 9300194, Japan Toyama Med & Pharmaceut Univ, Fac Med, Dept Immunol, Sugitani, Toyama 93001, Japan Toyama Med & Pharmaceut Univ Sugitani Toyama Japan 93001 ama 93001, Japan
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 1, volume: 12, anno: 2000,
pagine: 13 - 21
SICI:
0953-8194(200001)12:1<13:EOCSOH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC INTRACEREBROVENTRICULAR INFUSION; PITUITARY-GONADAL AXIS; LUTEINIZING-HORMONE; MESSENGER-RNA; INDUCED SUPPRESSION; NEUROENDOCRINE FUNCTIONS; REPRODUCTIVE FUNCTIONS; IMMOBILIZATION STRESS; NITRIC-OXIDE; CYCLING RATS;
Keywords:
stress; interleukin-1 beta; interleukin-2; gonadotropin-releasing hormone; hypothalamus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Ono, T Toyama Med & Pharmaceut Univ, Fac Med, Dept Physiol, Sugitani 2630,Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Sugitani 2630Sugitani Toyama Japan 9300194
Citazione:
K. Tanebe et al., "Effects of chronic stress on hypothalamic lnterleukin-1 beta, interleukin-2, and gonadotrophin-releasing hormone gene expression in ovariectomized rats", J NEUROENDO, 12(1), 2000, pp. 13-21

Abstract

The influence of chronic stress on the expression of interleukin (IL)-1 beta and IL-2 mRNAs in ovariectomized rat brains, and the physiological consequences of the expression of these cytokines on hypothalamic-pituitary-gonadal (HPG) activity were investigated. Using polymerase chain reaction (PCR)-assisted semiquantitative analysis, we demonstrated alterated expression of IL-1 beta and IL-2 mRNA during repeated cold stress; the expression of both IL-beta and IL-2 mRNA increased in the medial preoptic area and ventromedial hypothalamus, and decreased in the lateral hypothalamic area. In the arcuate nucleus/median eminence, IL-2 mRNA expression was dramatically decreased, in contrast to the increase in IL-1 beta mRNA expression. Concomitantanalysis of GnRH mRNA expression indicated significant suppression of GnRHsynthesis in the chronic phase, and a strong negative correlation with cytokine expression in the medial preoptic area. Similar results were obtainedin intact females exposed to this stress. These results, together with previous pharmacological studies, suggest that chronic stress may induce reproductive dysfunction through the effects of stress-induced expression of endogenous cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:31:16