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Titolo:
Genetically distinct strains of Candida albicans with elevated secretory proteinase production are associated with diarrhoea in hospitalized children
Autore:
Mathaba, LT; Paxman, AE; Ward, PB; Forbes, DA; Warmington, JR;
Indirizzi:
Univ Western Australia, QEII Med Ctr, Dept Microbiol, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia Curtin Univ Technol, Sch Biomed Sci, Bentley, WA 6102, Australia Curtin Univ Technol Bentley WA Australia 6102 Bentley, WA 6102, Australia Univ Western Australia, Princess Margaret Hosp, Dept Pediat, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia Univ Western Australia, Princess Margaret Hosp, Dept Microbiol, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 1, volume: 15, anno: 2000,
pagine: 53 - 60
SICI:
0815-9319(200001)15:1<53:GDSOCA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE MUTANTS; GERM TUBES; PATHOGENESIS; VIRULENCE; INVITRO; DNA;
Keywords:
adherence; Candida albicans; diarrhoea; restriction enzyme analysis; secretory Candida acid proteinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mathaba, LT Univ Western Australia, QEII Med Ctr, Dept Microbiol, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 , Australia
Citazione:
L.T. Mathaba et al., "Genetically distinct strains of Candida albicans with elevated secretory proteinase production are associated with diarrhoea in hospitalized children", J GASTR HEP, 15(1), 2000, pp. 53-60

Abstract

Background: Candida albicans has been implicated as the aetiological agentin a significant percentage of children with diarrhoea. The virulence properties of C. albicans strains associated with acute and chronic diarrhoea in hospitalized children were investigated. Methods: The genotypic relationships between the isolates were determined using restriction enzyme analysis and hybridization with a C. albicans-specific DNA probe, 27A. Results and Conclusion: In patients with acute and chronic diarrhoea, there is evidence for selection of specific, genetically distinct strains of C.albicans. Higher levels of secretory Candida acid proteinase produced by isolates from patients with acute diarrhoea may account for the more severe symptoms. However, the lower adherence of these isolates may predispose to the rapid (within 2 to 4 days) resolution of the condition. In patients with chronic diarrhoea the lower levels of proteinase produced correlate with the less severe symptoms, while the increased adherence may account for thepersistence of the infection. (C) 2000 Blackwell Science Asia Pty Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:48:56