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Titolo:
Role of norepinephrine in depression
Autore:
Delgado, PL; Moreno, FA;
Indirizzi:
Univ Arizona, Coll Med, Med Ctr, Dept Psychiat, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Ctr, Dept Psychiat, Tucson, AZ 85724 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
, volume: 61, anno: 2000, supplemento:, 1
pagine: 5 - 12
SICI:
0160-6689(2000)61:<5:RONID>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET ALPHA-2-ADRENERGIC RECEPTORS; ANTIDEPRESSANT-INDUCED REMISSION; MAJOR AFFECTIVE-DISORDERS; METHYL-PARA-TYROSINE; SUICIDE VICTIMS; BINDING-SITES; TRYPTOPHAN DEPLETION; BIOCHEMICAL CLASSIFICATION; CATECHOLAMINE DEPLETION; DESIPRAMINE TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Delgado, PL Univ Arizona, Coll Med, Med Ctr, Dept Psychiat, 7303 AHSC,1501N Campbell Ave, Tucson, AZ 85724 USA Univ Arizona 7303 AHSC,1501 N Campbell Ave Tucson AZ USA 85724
Citazione:
P.L. Delgado e F.A. Moreno, "Role of norepinephrine in depression", J CLIN PSY, 61, 2000, pp. 5-12

Abstract

This article reviews the role of norepinephrine (NE) and serotonin (5-HT) in depression and the therapeutic effects of antidepressant drugs from the perspective of human neurotransmitter depletion studies. The data reviewed suggest that both noradrenergic and serotonergic systems are involved in antidepressant action, but the specific impairment that underlies depression is unclear and is likely to vary among patients. Results from neurotransmitter depletion studies in depressed patients who have responded to treatmentsuggest that, while interactions between NE and 5-HT are likely, neither of these 2 neurotransmitter systems is the final common pathway for the therapeutic effect of antidepressant drugs. NE-selective antidepressant drugs appear to be primarily dependent on the availability of NE for their effects. Likewise, 5-HT-selective antidepressants appear to be primarily dependenton the availability of 5-HT for their effects. Antidepressants that cause effects on both noradrenergic and serotonergic systems - such as mirtazapine - may be dependent on the availability of both neurotransmitters for their effects. Neither 5-HT nor NE depletion induced clinical depression in healthy subjects or worsened depression in unmedicated symptomatic patients with major depression. This finding suggests that the cause of depression is more complex than just an alteration in the levels of 5-HT and/or NE. For some patients, depression may be more directly caused by dysfunction in brain areas or neuronal systems modulated by monoamine systems. We propose thatantidepressant drugs may enhance neurotransmission in normal noradrenergicor serotonergic neurons and, through a time-dependent bur as yet undiscovered process, restore function to brain areas modulated by monoamine neurons. Future research should focus on understanding the adaptive changes thar follow enhancement of synaptic levels of monoamines in neuronal circuits of the frontal cortex, amygdala, and hippocampus. Research investigating the neurobiology of depression may be more informed if the focus is shifted to investigating areas of the brain modulated by monoamine systems rather than the monoamine systems themselves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:06:27