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Titolo:
C282Y mutation in the HLA-H gene is not a risk factor for patients with myocardial infarction
Autore:
Annichino-Bizzacchi, JM; Saad, STO; Arruda, VR; Ramires, JAF; Siqueira, LH; Chiaparini, LC; Mansur, AP;
Indirizzi:
UNICAMP, Hemoctr, FCM Campinas, Campinas, SP, Brazil UNICAMP Campinas SP Brazil , Hemoctr, FCM Campinas, Campinas, SP, Brazil Univ Sao Paulo, Inst Coracao, Sao Paulo, Brazil Univ Sao Paulo Sao PauloBrazil Paulo, Inst Coracao, Sao Paulo, Brazil FCM UNICAMP, Disciplina Cardiol, Campinas, SP, Brazil FCM UNICAMP Campinas SP Brazil Disciplina Cardiol, Campinas, SP, Brazil
Titolo Testata:
JOURNAL OF CARDIOVASCULAR RISK
fascicolo: 1, volume: 7, anno: 2000,
pagine: 37 - 40
SICI:
1350-6277(200002)7:1<37:CMITHG>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; IRON; HEMOCHROMATOSIS; FERRITIN; MEN;
Keywords:
myocardial infarction; hemochromatosis; C282Y mutation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Annichino-Bizzacchi, JM UNICAMP, Hemoctr, FCM Campinas, CP 6198, Campinas,SP, Brazil UNICAMP CP 6198 Campinas SP Brazil as, SP, Brazil
Citazione:
J.M. Annichino-Bizzacchi et al., "C282Y mutation in the HLA-H gene is not a risk factor for patients with myocardial infarction", J CARD RISK, 7(1), 2000, pp. 37-40

Abstract

Background Iron is suspected to play a role in the development of atherosclerosis and in the progression of the disease, and consequently in myocardial infarction. Authors of a recent study identified a mutation in HLA-H gene, C282Y, that is an excellent marker for hemochromatosis, which is the most common cause of iron overload. There is a high prevalence of carriers of heterozygous hemochromatosis, most of whom are asymptomatic even with abnormalities of iron metabolism. Objective To study C282Y mutation in the HLA-H gene of 173 survivors of myocardial infarction matched with 172 controls by age, race, and sex, and 119 patients upon diagnosis of acute myocardial infarction. Methods Identification of the mutation was performed by PCR amplification of the DNA fragment followed by RsaI digestion. Results The prevalence of heterozygotes for the mutated allele both among patients and among controls was 1.74%. None of the 119 patients studied upon diagnosis was a carrier of the mutation. Conclusion Our data suggested that the most common cause of iron overload is not associated with myocardial infarction. J Cardiovasc Risk 7: 37-40 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:03:58