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Titolo:
Effect of long-term cholesterol-lowering treatment with HMG-CoA reductase inhibitor (simvastatin) on myocardial perfusion evaluated by thallium-201 single photon emission computed tomography
Autore:
Hosokawa, R; Nohara, R; Li, LX; Tamaki, S; Hashimoto, T; Tanaka, M; Miki, S; Sasayama, S;
Indirizzi:
Kyoto Univ Hosp, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan Kyoto Univ Hosp Kyoto Japan Sch Med, Dept Cardiovasc Med, Kyoto, Japan Takeda Hosp, Kyoto, Japan Takeda Hosp Kyoto JapanTakeda Hosp, Kyoto, Japan Ijinkai Takeda Hosp, Kyoto, Japan Ijinkai Takeda Hosp Kyoto JapanIjinkai Takeda Hosp, Kyoto, Japan Rakuwakai Otowa Hosp, Kyoto, Japan Rakuwakai Otowa Hosp Kyoto JapanRakuwakai Otowa Hosp, Kyoto, Japan Mitsubishi Hosp, Kyoto, Japan Mitsubishi Hosp Kyoto JapanMitsubishi Hosp, Kyoto, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 3, volume: 64, anno: 2000,
pagine: 177 - 182
SICI:
0047-1828(200003)64:3<177:EOLCTW>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HIBERNATING MYOCARDIUM; CLINICAL EVENTS; HEART-DISEASE; PRAVASTATIN; ENDOTHELIUM; THERAPY; REGRESSION; HYPERCHOLESTEROLEMIA; VASOMOTION;
Keywords:
cholesterol; HMG-CoA reductase inhibitor (simvastatin); HDL cholesterol; myocardial perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Nohara, R Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawaracho, Kyoto 606, Japan Kyoto Univ 54 Kawaracho Kyoto Japan 606 racho, Kyoto 606, Japan
Citazione:
R. Hosokawa et al., "Effect of long-term cholesterol-lowering treatment with HMG-CoA reductase inhibitor (simvastatin) on myocardial perfusion evaluated by thallium-201 single photon emission computed tomography", JPN CIRC J, 64(3), 2000, pp. 177-182

Abstract

Fifteen patients with either angina pectoris or old myocardial infarction,who had positive Tl-201 single photon emission computed tomography (SPECT)imaging and coronary sclerosis of more than 50%, were treated with an HMG-CoA reductase inhibitor (simvastatin) for more than 1 year. They were compared with an untreated control group (n=25). Total cholesterol decreased 22%and high-density lipoprotein (HDL) increased 9% with simvastatin; both changes were significantly different from those in controls. Long-term simvastatin induced improvement of myocardial perfusion on Tl-201 SPECT images both during exercise and at rest, which was also significantly different from controls. In addition, the improvement of myocardial perfusion on Tl-201 SPECT images was clearly related to the improvements in cholesterol values, especially nonHDL cholesterol. Thus, the greater the decrease in nonHDL cholesterol, the greater the improvement in myocardial perfusion at rest or during exercise with long-term treatment using an HMG-CoA reductase inhibitor. These findings indicate that the improvements in cholesterol values causedby HMG-CoA reductase inhibitor therapy are related to improvements of myocardial perfusion seen on Tl-201 SPECT images.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:27:48