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Titolo:
Multivariate dynamic analysis of cerebral blood flow regulation in humans
Autore:
Panerai, RB; Simpson, DM; Deverson, ST; Mahony, P; Hayes, P; Evans, DH;
Indirizzi:
Univ Leicester, Leicester Royal Infirm, Fac Med, Div Med Phys, Leicester LE1 5WW, Leics, England Univ Leicester Leicester Leics England LE1 5WW er LE1 5WW, Leics, England Leicester Royal Infirm, Dept Med Phys, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WW WW, Leics, England Leicester Royal Infirm, Dept Surg, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WW WW, Leics, England
Titolo Testata:
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
fascicolo: 3, volume: 47, anno: 2000,
pagine: 419 - 423
SICI:
0018-9294(200003)47:3<419:MDAOCB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREQUENCY-DOMAIN ANALYSIS; SPONTANEOUS FLUCTUATIONS; CARBON-DIOXIDE; AUTOREGULATION; PRESSURE; DOPPLER; ARTERY; ULTRASOUND; VELOCITY;
Keywords:
cerebral autoregulation; cerebral blood flow; cerebrovascular reactivity; cross-correlation analysis; Doppler measurements; end-tidal CO2; system identification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Panerai, RB Univ Leicester, Leicester Royal Infirm, Fac Med, Div Med Phys,Leicester LE1 5WW, Leics, England Univ Leicester Leicester Leics England LE1 5WW Leics, England
Citazione:
R.B. Panerai et al., "Multivariate dynamic analysis of cerebral blood flow regulation in humans", IEEE BIOMED, 47(3), 2000, pp. 419-423

Abstract

The contributions of beat-to-beat changes in mean arterial blood pressure (MABP) and breath-by-breath fluctuations in end-tidal CO2 (EtCO2) as determinants of the spontaneous variability of cerebral blood flow velocity (CBFV) were studied in 16 normal subjects at rest. The two input variables (MABPand EtCO2) had significant cross correlations with CBFV but not between them. Transfer functions were estimated as the multivariate least mean squarefinite impulse response causal filters. MABP showed a very significant effect in explaining CBFV variability (p < 10(-11), Fisher's aggregated p test) and the model mean square error was significantly reduced (p < 0.001) by also including the contribution of EtCO2. The estimated mean CBFV step response to MABP displayed the characteristic return to baseline caused by the cerebral autoregulatory response. The corresponding response to EtCO2 showed a gradual rise taking approximately 10 s to reach of plateau of 2.5%/mmHg. This study demonstrated that spontaneous fluctuations in EtCO2 can help to explain the CBFV variability at rest if appropriate signal processing techniques are employed to address the limited power and bandwith of the breath-by-breath EtCO2 signal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 22:33:22