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Titolo:
Serum concentrations of dimeric inhibins, activin A, gonadotrophins and ovarian steroids during the menstrual cycle in older women
Autore:
Muttukrishna, S; Child, T; Lockwood, GM; Groome, NP; Barlow, DH; Ledger, WL;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU t & Gynaecol, Oxford OX3 9DU, England Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England Oxford Brookes Univ Oxford England OX3 0BP Sci, Oxford OX3 0BP, England
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 3, volume: 15, anno: 2000,
pagine: 549 - 556
SICI:
0268-1161(200003)15:3<549:SCODIA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; PITUITARY-CELLS INVITRO; MENOPAUSAL TRANSITION; AGE; SECRETION; FLUID; FSH; LH;
Keywords:
activin A; inhibin A; inhibin B; ovary; perimenopause;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Muttukrishna, S Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ford OX3 9DU, England
Citazione:
S. Muttukrishna et al., "Serum concentrations of dimeric inhibins, activin A, gonadotrophins and ovarian steroids during the menstrual cycle in older women", HUM REPR, 15(3), 2000, pp. 549-556

Abstract

The transition from regular ovarian cyclicity to menopause is associated with a rise in the circulating concentrations of follicle stimulating hormone (FSH), despite the maintenance of serum oestradiol concentrations during the perimenopause. The aim of this study was to compare the pattern of secretion of dimeric inhibins, activin A, gonadotrophins and steroids in regularly cycling women of 40-50 years with normal and raised early follicular phase serum FSH concentrations and young women (25-33 years) during the menstrual cycle. Blood samples were taken prospectively almost daily throughout the menstrual cycle. Women recruited were classified into three groups: (i)older women with normal FSH [(ON-FSH), day 3 FSH <8 mIU/ mi, n = 10]; (ii)older women with raised FSH [(R-FSH), day 3 FSH >8mIU/ml, n = 6] and (iii)young normal FSH (YN-FSH) women, age 25-32 years (n = 6), Cyclic patterns of serum inhibins and activin A were similar in the ON-FSH and YN-FSH groups. The R-FSH group had significantly lower concentrations of inhibin A pricer to the luteinizing hormone (LH) surge and in the mid-luteal phase and lower concentrations of inhibin B in the early follicular phase compared withthe ON-FSH group. Serum concentrations of activin A, progesterone and oestradiol were similar in all three groups. It is concluded from this study that the rise in early follicular phase serum FSH in older women is associated with a decrease in circulating concentrations of inhibin B in the early follicular phase. However, lower circulating concentrations of inhibin A in the luteal phase of the R-FSH group may also contribute to the rise in early follicular phase FSH concentrations during the menstrual cycle, although further studies with larger numbers are required to confirm this observation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:59:34