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Titolo:
Testing mode of inheritance of a candidate mutation at a quantitative trait locus
Autore:
Rabinowitz, D; Zanchi, A; Schaumberg, D; Krolewski, A;
Indirizzi:
Columbia Univ, Dept Stat, New York, NY 10027 USA Columbia Univ New York NY USA 10027 iv, Dept Stat, New York, NY 10027 USA Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Joslin Diabet Ctr, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ BostonMA USA 02115 Sch Med, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 event Med, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA
Titolo Testata:
HUMAN HEREDITY
fascicolo: 3, volume: 50, anno: 2000,
pagine: 184 - 188
SICI:
0001-5652(200005/06)50:3<184:TMOIOA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; DISEQUILIBRIUM; RISK;
Keywords:
additivity; ascertainment; association; diabetic nephropathy; disequilibrium; dominant; linkage analysis; population admixture; recessive; transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Rabinowitz, D Columbia Univ, Dept Stat, Math Bldg,Mail Code 4403,Broadway & 120th St, New York, NY 10027 USA Columbia Univ Math Bldg,Mail Code 4403,Broadway & 120th St New York NY USA 10027
Citazione:
D. Rabinowitz et al., "Testing mode of inheritance of a candidate mutation at a quantitative trait locus", HUMAN HERED, 50(3), 2000, pp. 184-188

Abstract

Here is presented an approach to testing whether the effect of a candidategene on a quantitative trait is dominant and for testing whether the effect is recessive, The approach uses parental genotype information in nuclear families to adjust for bias due to population admixture, The approach is applicable regardless of the nature of the sampling, The results of an application of the methods to a candidate mutation for diabetic nephropathy are used for illustration. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 19/09/20 alle ore 17:30:53