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Titolo:
Renal endothelin in hypertension
Autore:
Pollock, DM;
Indirizzi:
Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 asc Biol Ctr, Augusta, GA 30912 USA
Titolo Testata:
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
fascicolo: 2, volume: 9, anno: 2000,
pagine: 157 - 164
SICI:
1062-4821(200003)9:2<157:REIH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY COLLECTING DUCT; SALT-SENSITIVE HYPERTENSION; PROXIMAL STRAIGHT TUBULE; RAT MESANGIAL CELLS; VASCULAR HYPERTROPHY; RECEPTOR SUBTYPES; BLOOD-PRESSURE; HUMAN KIDNEY; IN-VITRO; IMMUNOREACTIVE ENDOTHELIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Pollock, DM Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 , Augusta, GA 30912 USA
Citazione:
D.M. Pollock, "Renal endothelin in hypertension", CURR OP NEP, 9(2), 2000, pp. 157-164

Abstract

Due to the potent vasoconstrictor action of endothelin-l and its synthesisthroughout the vasculature and other tissues, most investigators believe that it is an active participant in the pathogenesis of hypertension. However, the autocrine and paracrine nature of the endothelin system has made itsrole difficult to define. In recent years, it has become apparent that endothelin-l contributes to the regulation of renal salt and water excretion and that it is a major contributor to the hypertension associated with salt-dependency. Evidence suggests that endothelin-l within the renal medulla isactivated in conditions of salt loading and inhibits reabsorption of sodium in a nitric oxide-dependent manner. Blockade of endothelin A receptors lowers arterial pressure in animal models of salt-dependent hypertension. Furthermore, circulating levels of endothelin-l are generally higher in African-Americans compared to white Americans as is the prevalence of salt-dependent hypertension. Therefore, if would appear that use of endothelin A-selective receptor antagonists should be targeted to those individuals at risk for salt-dependent hypertension. Blockade of endothelin B receptors would not be desirable because of their important role in eliminating a salt load. Curr Opin Nephrol Hypertens 9:157-164. (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 21/09/20 alle ore 16:16:18