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Titolo:
SOURCE OF CIRCULATING LEVELS OF INHIBIN-A, PRO-ALPHA-C-CONTAINING INHIBINS AND ACTIVIN-A IN EARLY-PREGNANCY
Autore:
MUTTUKRISHNA S; CHILD TJ; GROOME NP; LEDGER WL;
Indirizzi:
JOHN RADCLIFFE HOSP,NUFFIELD DEPT OBSTET & GYNAECOL OXFORD OX3 9DU ENGLAND OXFORD BROOKES UNIV,SCH BIOL & MOL SCI OXFORD OX3 0BP ENGLAND
Titolo Testata:
Human reproduction
fascicolo: 5, volume: 12, anno: 1997,
pagine: 1089 - 1093
SICI:
0268-1161(1997)12:5<1089:SOCLOI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MENSTRUAL-CYCLE; HUMAN CHORIONIC-GONADOTROPIN; DIMERIC INHIBIN; HUMAN-PLACENTA; IMMUNOREACTIVE INHIBIN; IMMUNOACTIVE INHIBIN; SERUM CONCENTRATIONS; DOWNS-SYNDROME; PROGESTERONE; LOCALIZATION;
Keywords:
ACTIVIN; FETUS; INHIBIN; PLACENTA; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S. Muttukrishna et al., "SOURCE OF CIRCULATING LEVELS OF INHIBIN-A, PRO-ALPHA-C-CONTAINING INHIBINS AND ACTIVIN-A IN EARLY-PREGNANCY", Human reproduction, 12(5), 1997, pp. 1089-1093

Abstract

It is now established that the glycoprotein hormone inhibin is produced by primate granulosa cells, corpus luteum and trophoblast of human placenta, This study was designed to investigate the major source of inhibins and activin A in early pregnancy using a novel panel of assayswith high specificity and sensitivity. A total of 12 women (aged 20-35 years) with singleton pregnancy undergoing first trimester (group 1:6-8; group 2: 8-10; group 3: 10-12 weeks of gestation) termination ofpregnancy (TOP) was recruited for the study Blood samples were taken before TOP, every 15 min for the first hour and hourly for the next 3 h after TOP (total of 4 h of measurements), Circulating concentrationsof inhibin A, pro alpha C, activin A, human chorionic gonadotrophin (HCG), oestradiol and progesterone were higher in early pregnancy than at any stage of the menstrual cycle, Peripheral concentrations of inhibin A and activin A were significantly decreased within the first hourin all three groups and gradually decreased to even lower concentrations within the study period, Pro alpha C concentrations decreased within the first hour and then remained unaltered during the next 3 h, Similarly, HCG, oestradiol and progesterone concentrations in circulationdecreased substantially within 3 h of TOP, Correlation analyses showed a significant positive correlation (P < 0.001) between inhibin A, activin A, HCG, and oestradiol concentrations throughout the study period, In summary, this study shows that the fete-placental unit is the major source of increased circulating concentrations of inhibin A in early pregnancy, Activin A is produced by the fete-placental unit and thecorpus luteum, Pro alpha C-containing inhibins are mainly secreted bythe corpus luteum in early pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:54:25