Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Levosulpiride for dyspepsia and emesis - A review of its pharmacology, efficacy and tolerability
Autore:
Corazza, GR; Tonini, M;
Indirizzi:
Univ Pavia, Dept Internal Med & Therapeut, Div Gastroenterol, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 , Div Gastroenterol, I-27100 Pavia, Italy Univ Pavia, Div Expt & Clin Pharmacol, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 pt & Clin Pharmacol, I-27100 Pavia, Italy
Titolo Testata:
CLINICAL DRUG INVESTIGATION
fascicolo: 2, volume: 19, anno: 2000,
pagine: 151 - 162
SICI:
1173-2563(200002)19:2<151:LFDAE->2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; FUNCTIONAL DYSPEPSIA; L-SULPIRIDE; METOCLOPRAMIDE; CROSSOVER; SAFETY; GASTROPARESIS; CHEMOTHERAPY; DOMPERIDONE; PREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Corazza, GR Univ Pavia, Dept Internal Med & Therapeut, Div Gastroenterol, Via Palestro3, I-27100 Pavia, Italy Univ Pavia Via Palestro 3 Pavia Italy I-27100 00 Pavia, Italy
Citazione:
G.R. Corazza e M. Tonini, "Levosulpiride for dyspepsia and emesis - A review of its pharmacology, efficacy and tolerability", CLIN DRUG I, 19(2), 2000, pp. 151-162

Abstract

Objective: To review the clinical pharmacology of levosulpiride and establish its efficacy and tolerability profile in the treatment of patients withdyspepsia and emesis. Methods: A critical review was conducted to assess the clinical pharmacology, therapeutic efficacy and tolerability of levosulpiride and to establishwhether it offers any advantage over currently available therapies. Results: Levosulpiride has been evaluated in 15 double-blind, randomised clinical trials in patients with dyspepsia (n = 1818, of whom 676 were treated with levosulpiride) and Il clinical trials in patients with emesis (n = 718, of whom 383 were treated with levosulpiride). It was shown to be effective in the treatment of dyspepsia (functional or organic dyspepsia, diabetic gastroparesis and reflux oesophagitis), the prevention and treatment of iatrogenic emesis resulting from pharmacological agents (anaesthetics, anticancer chemotherapy, calcitonin), and the treatment of severe non-iatrogenic nausea and vomiting. The incidence of adverse events was 11% in 840 patients with dyspepsia; most of them were mild and they resulted in treatment discontinuation in only eight (0.9%) cases. Conclusions: Levosulpiride should be considered among the drugs of choice for the treatment of various forms of dyspepsia and emesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:22:40