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Titolo:
Proteases in gastrointestinal neoplastic diseases
Autore:
Herszenyi, L; Plebani, M; Carraro, P; De Paoli, M; Roveroni, G; Cardin, R; Foschia, F; Tulassay, Z; Naccarato, R; Farinati, F;
Indirizzi:
Univ Padua, Cattedra Malattie Apparato Digerente, Dipartimento Sci Chirurg& Gastroenterol, Div Gastroenterol, I-35128 Padua, Italy Univ Padua PaduaItaly I-35128 , Div Gastroenterol, I-35128 Padua, Italy Univ Padua, Dipartimento Med Lab, Cent Lab, I-35128 Padua, Italy Univ Padua Padua Italy I-35128 o Med Lab, Cent Lab, I-35128 Padua, Italy Semmelweis Univ Med, Sch Med, Dept Med 2, Budapest, Hungary Semmelweis Univ Med Budapest Hungary Med, Dept Med 2, Budapest, Hungary
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 2, volume: 291, anno: 2000,
pagine: 171 - 187
SICI:
0009-8981(20000215)291:2<171:PIGND>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; EXTRACELLULAR-MATRIX DEGRADATION; HUMAN COLORECTAL-CARCINOMA; HUMAN COLON-CARCINOMA; CATHEPSIN-B; UROKINASE RECEPTOR; GASTRIC-CANCER; CELL-LINES; PROTEOLYTIC-ENZYMES; BREAST CARCINOMAS;
Keywords:
cancer; cathepsin; gastrointestinal tract; plasminogen activator; prognosis; protease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Farinati, F Univ Padua, Cattedra Malattie Apparato Digerente, DipartimentoSci Chirurg& Gastroenterol, Div Gastroenterol, Via Giustiniani 2, I-35128 Padua, Italy Univ Padua Via Giustiniani 2 Padua Italy I-35128 Padua, Italy
Citazione:
L. Herszenyi et al., "Proteases in gastrointestinal neoplastic diseases", CLIN CHIM A, 291(2), 2000, pp. 171-187

Abstract

Cysteine and serine proteases are involved in cancer invasion and metastasis. In the past few years we investigated the tissue levels of these proteases in gastric cancer (GC), gastric precancerous changes (CAG), colorectal cancer (CRC) and the plasma and serum levels of proteases in several gastrointestinal rumours. using ELISA methods. Significantly higher antigen levels were found not only in GC tissue but also in CAG with respect to the levels found normal tissue; with respect to GAG, patients with dysplasia had higher levels than patients without dysplasia. The same findings were obtained in CRC. In general protease levels correlated with the major histomorphological parameters, such as grading and histotype in GC as well as in CRC. Tissue protease levels had a strong prognostic impact in GC, in which UPA was singled out by multivariate analysis as the major prognostic factor, and CRC. The plasma levels of urokinase-type plasminogen activator (UPA) and the serum levels of cathepsin B were significantly increased in patients withgastrointestinal tumours. In conclusions, cysteine and serine proteases may have a part not only in GC and CRC invasion and metastasis, but also in the progression of gastric precancerous changes into cancer. They are strongprognostic factors in GC and CRC. These proteases may also have a role as tumour markers in the early diagnosis of gastrointestinal tract rumours. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 10:43:56