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Titolo:
Muscarinic M-3 receptor subtype gene expression in the human heart
Autore:
Hellgren, I; Mustafa, A; Riazi, M; Suliman, I; Sylven, C; Adem, A;
Indirizzi:
Huddinge Univ Hosp, Karolinska Inst, Novum, Clin Res Ctr,Dept Cardio, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 dio, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Stockholm, SwedenHuddinge Univ Hosp Stockholm Sweden pt Clin Neurosci, Stockholm, Sweden Huddinge Univ Hosp, Karolinska Inst, Dept Orthoped Surg, Stockholm, SwedenHuddinge Univ Hosp Stockholm Sweden pt Orthoped Surg, Stockholm, Sweden
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 1, volume: 57, anno: 2000,
pagine: 175 - 180
SICI:
1420-682X(20000120)57:1<175:MMRSGE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR; CHICK HEART; MESSENGER-RNAS; CLONING; IDENTIFICATION; PIRENZEPINE; VENTRICLE; SEQUENCE; BINDING; ATRIUM;
Keywords:
muscarinic receptor; subtypes; human; heart failure; ventricle; atrium; mRNA; protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hellgren, I Huddinge Univ Hosp, Karolinska Inst, Novum, Clin Res Ctr,Dept Cardio, 5th Floor, S-14186 Huddinge, Sweden Huddinge Univ Hosp 5th Floor Huddinge Sweden S-14186 , Sweden
Citazione:
I. Hellgren et al., "Muscarinic M-3 receptor subtype gene expression in the human heart", CELL MOL L, 57(1), 2000, pp. 175-180

Abstract

The heart is an important target organ for cholinergic function. In this study, muscarinic receptor subtype(s) in the human heart were determined using reverse transcription-polymerase chain reaction. Our results demonstrated muscarinic receptor M-2 and M-3 subtype RNA in left/right atria/ventricles of donor hearts. Receptor autoradiography analysis using selective mus- carinic ligands indicated an absence of M-1 receptor subtype in the human heart. The level of muscarinic receptor binding in atria was two to three times greater than in ventricles. Our results suggest that muscarinic receptors in the human heart are of the M-2 and M-3 subtypes. This is the first report of M-3 receptors in the human myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 05:39:18