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Titolo:
Expression of matrix metalloproteinase-2 in glial and neuronal tumor cell lines: inverse correlation with proliferation rate
Autore:
Thier, M; Roeb, E; Breuer, B; Bayer, TA; Halfter, H; Weis, J;
Indirizzi:
Univ Bern, Inst Pathol, Div Neuropathol, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 europathol, CH-3010 Bern, Switzerland Aachen Tech Univ, RWTH, Inst Neuropathol, D-52057 Aachen, Germany Aachen Tech Univ Aachen Germany D-52057 opathol, D-52057 Aachen, Germany Aachen Tech Univ, RWTH, Med Clin 3, D-52057 Aachen, Germany Aachen Tech Univ Aachen Germany D-52057 Clin 3, D-52057 Aachen, Germany Univ Bonn, Inst Neuropathol, D-53127 Bonn, Germany Univ Bonn Bonn Germany D-53127 , Inst Neuropathol, D-53127 Bonn, Germany Univ Munster, Neurol Clin, D-48129 Munster, Germany Univ Munster MunsterGermany D-48129 urol Clin, D-48129 Munster, Germany
Titolo Testata:
CANCER LETTERS
fascicolo: 1-2, volume: 149, anno: 2000,
pagine: 163 - 170
SICI:
0304-3835(20000228)149:1-2<163:EOMMIG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS LESIONS; HUMAN BRAIN-TUMORS; EXTRACELLULAR-MATRIX; GELATINASE-A; HUMAN GLIOMA; IN-VITRO; TISSUE INHIBITOR; DIFFERENTIAL EXPRESSION; ASTROCYTOMA MIGRATION;
Keywords:
brain tumors; matrix metalloproteinase-2; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Weis, J Univ Bern, Inst Pathol, Div Neuropathol, CH-3010 Bern, SwitzerlandUniv Bern Bern Switzerland CH-3010 ol, CH-3010 Bern, Switzerland
Citazione:
M. Thier et al., "Expression of matrix metalloproteinase-2 in glial and neuronal tumor cell lines: inverse correlation with proliferation rate", CANCER LETT, 149(1-2), 2000, pp. 163-170

Abstract

The expression of matrix metalloproteinases (MMPs) has been found to be positively correlated to the degree of malignancy in gliomas, indicating thatpoorly differentiated brain tumor cells produce more MMPs than differentiated ones, We determined the production of active MMP-2 in five glial (U138MG, U373MG, A172, C6, GOS-3), two neuronal (SK-N-SH, SK-N-MC), and two pluripotent cell lines with facultative neuronal and glial differentiation (P19 and NT2) by gelatin zymography. The MMP-2 activity profiles were compared to the proliferative activities of the cell lines. MMP-2 expression varied from barely existent (P19 cells) to strong (U138MG and SK-N-SH). Interestingly, for the cell lines with high MMP-2 expression levels, low proliferativeactivities were recorded, and vice versa. Retinoic acid induced neuronal differentiation and a reduction of proliferation of P19 cells; the differentiated cells produced significantly more MMP-2 than untreated cells. Upon confluency, GOS-3 cells showed reduced proliferation, but increased MMP expression. Thus, proliferative activity was inversely correlated to MMP-2 expression in the tumor cell lines analyzed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:19:50