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Titolo:
A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea - A review
Autore:
Fujiki, H; Suganuma, M; Okabe, S; Sueoka, E; Suga, K; Imai, K; Nakachi, K;
Indirizzi:
Saitama Canc Ctr, Res Inst, Ina, Saitama 3620806, Japan Saitama Canc Ctr Ina Saitama Japan 3620806 t, Ina, Saitama 3620806, Japan
Titolo Testata:
CANCER DETECTION AND PREVENTION
fascicolo: 1, volume: 24, anno: 2000,
pagine: 91 - 99
SICI:
0361-090X(2000)24:1<91:ANCOTP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OKADAIC ACID CLASS; BALB/3T3 CELL-TRANSFORMATION; PROTEIN-KINASE-C; MOUSE SKIN; GLANDULAR STOMACH; PHOSPHATASE-2A; LIVER; INHIBITION; EXPRESSION; DINOPHYSISTOXIN-1;
Keywords:
okadaic acid; tautomycin; protein phosphatases 1 and 2A; cancer prevention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Fujiki, H Saitama Canc Ctr, Res Inst, Ina, Saitama 3620806, Japan Saitama Canc Ctr Ina Saitama Japan 3620806 itama 3620806, Japan
Citazione:
H. Fujiki et al., "A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea - A review", CANCER DET, 24(1), 2000, pp. 91-99

Abstract

The study of tumor promotion in rodent carcinogenesis using chemical tumorpromoters has revealed various tumor promotion pathways, such as the 12-O-tetradecanoylphorbol-13-acetate (TPA) pathway mediated through activation of protein kinase C, and the okadaic acid pathway mediated through inhibition of protein phosphatases 1 and 2A (PP-1 and PP-2A). We previously demonstrated that application of TPA and okadaic acid induced tumor necrosis factor-alpha (TNF-alpha) gene expression in mouse skin, bur that tautomycin, which is an inhibitor of PP-I and PP-2A and not a tumor promoter on mouse skin,did not. Moreover, we found that TNF-alpha stimulated transformation of BALB/3T3 cells initiated with 3-methylcholanthrene 1,000 times stronger than did TPA (Cancer Res. 53, 1982-1985, 1993). This evidence demonstrates a link between the okadaic acid pathway and the endogenous tumor promotion pathway of TNF-alpha. Recently we presented the first evidence that tumor promotion in TNF-alpha(-/-) mice was significantly depressed compared with TNF-alpha(+/+) mice. Thus, in human carcinogenesis, we think that TNF-alpha and other inflammatory cytokines in preneoplastic lesion stimulate tumor promotion and progression of initiated cells as well as premalignant cells. The first part of this paper reports on this TNF-alpha tumor promotion pathway. In the second part, we report a promising screening method for cancer preventive agents, based on evidence that pretreatment with agents such as tamoxifen, sulindac, 1 alpha, 25-(OH)(2) vitamin D-3, quercetin, caffeic acid phenethyl ester, and (-)-epigallocatechin gallate (EGCG) commonly inhibited TNF-alpha release from BALB/3T3 cells induced by okadaic acid. EGCG, the main constituent of Japanese green tea, and green tea itself are acknowledgedcancer preventives in Japan, and this paper presents evidence of their effectiveness in both a high-risk group and the general population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:47:31