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Titolo:
Renal function and serum concentration of five tumor markers (TATI, SCC, CYFRA 21-1, TPA, and TPS) in patients without evidence of neoplasia
Autore:
Tramonti, G; Ferdeghini, M; Donadio, C; Norpoth, M; Annichiarico, C; Bianchi, R; Bianchi, C;
Indirizzi:
Univ Pisa, Sez Nefrol, Dipartimento Med Interna, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 partimento Med Interna, I-56100 Pisa, Italy
Titolo Testata:
CANCER DETECTION AND PREVENTION
fascicolo: 1, volume: 24, anno: 2000,
pagine: 86 - 90
SICI:
0361-090X(2000)24:1<86:RFASCO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; NEURON-SPECIFIC ENOLASE; TRYPSIN-INHIBITOR TATI; HEMODIALYSIS-PATIENTS; CARCINOEMBRYONIC ANTIGEN; ALPHA-FETOPROTEIN; CYSTATIN-C; INSUFFICIENCY; CREATININE; FAILURE;
Keywords:
glomerular filtration rate; low molecular weight proteins; renal failure; tumor markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tramonti, G Osped Santa Chiara, Med Clin, Sez Nefrol, Dipartimento Med Interna, Via Roma 67, I-56126 Pisa, Italy Osped Santa Chiara Via Roma 67 PisaItaly I-56126 Pisa, Italy
Citazione:
G. Tramonti et al., "Renal function and serum concentration of five tumor markers (TATI, SCC, CYFRA 21-1, TPA, and TPS) in patients without evidence of neoplasia", CANCER DET, 24(1), 2000, pp. 86-90

Abstract

The aim of this study was to evaluate the relationship between renal function and the blood level of some tumor markers that are low molecular weightproteins, that is, tumor-associated trypsin inhibitor (TATI), squamous cells carcinoma antigen (SCC), cytokeratin 19 fragments (CYFRA 21-1), tissue polypeptide antigen (TPA), and M3-specific epitope of tissue polypeptide antigen (TPS). In 41 adult patients without evidence of neoplastic disease, glomerular filtration rate (GFR) and the blood levels of creatinine and of the tumor markers were determined. The decrease in GFR was accompanied by an increase in serum levels of TATI, SCC, CYFRA 21-1, and TPA. The serum levelof tumor markers increased particularly when GFR fell below 40 ml/min. On the basis of these results, the renal function must be taken into account for the clinical evaluation of the studied tumor markers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:54:24