Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Anorexigenic cocaine- and amphetamine-regulated transcript peptide intensifies fear reactions in rats
Autore:
Kask, A; Schioth, HB; Mutulis, F; Wikberg, JES; Rago, L;
Indirizzi:
Univ Tartu, Dept Pharmacol, EE-50411 Tartu, Estonia Univ Tartu Tartu Estonia EE-50411 ept Pharmacol, EE-50411 Tartu, Estonia Univ Uppsala, Dept Pharmaceut Pharmacol, Uppsala, Sweden Univ Uppsala Uppsala Sweden Dept Pharmaceut Pharmacol, Uppsala, Sweden Melacure Therapeut, Uppsala, Sweden Melacure Therapeut Uppsala SwedenMelacure Therapeut, Uppsala, Sweden
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 857, anno: 2000,
pagine: 283 - 285
SICI:
0006-8993(20000228)857:1-2<283:ACAATP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN; CART;
Keywords:
cocaine- and amphetamine-regulated transcript anxiety; fear; stress; ingestive behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Kask, A Univ Tartu, Dept Pharmacol, Ravila 19, EE-50411 Tartu, Estonia Univ Tartu Ravila 19 Tartu Estonia EE-50411 -50411 Tartu, Estonia
Citazione:
A. Kask et al., "Anorexigenic cocaine- and amphetamine-regulated transcript peptide intensifies fear reactions in rats", BRAIN RES, 857(1-2), 2000, pp. 283-285

Abstract

An increasing number of appetite-regulating peptides are being discovered. The list of regulators inhibiting food intake is considerably longer than that of appetite stimulators, In many cases, the peptides inhibiting food intake facilitate fear reactions, whereas the majority of the agents reducing anxiety responses stimulate appetite. Cocaine- and amphetamine-regulated transcript (CART) cDNA was isolated from hypothalamic libraries and CART was reported to inhibit food intake and to mediate the anorectic effects of leptin, Here, we show that the active core fragment of CART (CART(89-103), 0.04-5.0 nmol) injected into lateral cerebral ventricle not only inhibits food intake, but also causes a dose-dependent increase in anxiety-like reactions in elevated plus-maze test. Intracerebroventricular administration of CART(82-103) (0.04-5.0 nmol) did not inhibit water intake and did not affectspontaneous locomotor activity in the open field test ruling out unspecific effects of the peptide. Our results suggest that CART could be an endogenous factor in the brain mediating the effects of stress on appetite. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:28:07