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Titolo:
The effect of delta-9-tetrahydrocannabinol on forebrain ischemia in rat
Autore:
Louw, DF; Yang, FW; Sutherland, GR;
Indirizzi:
Univ Calgary, Foothills Hosp, Dept Clin Neurosci, Calgary, AB T2N 2T9, Canada Univ Calgary Calgary AB Canada T2N 2T9 rosci, Calgary, AB T2N 2T9, Canada
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 857, anno: 2000,
pagine: 183 - 187
SICI:
0006-8993(20000228)857:1-2<183:TEODOF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ISCHEMIA; BRAIN; RECEPTOR; HU-211; INJURY;
Keywords:
forebrain ischemia; delta-9-tetrahydrocannabinol; striatum; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sutherland, GR Foothills Prov Gen Hosp, Seaman Family MR Res Ctr, 1403-29 St NW, Calgary,AB T2N 2T9, Canada Foothills Prov Gen Hosp 1403-29 St NW Calgary AB Canada T2N 2T9
Citazione:
D.F. Louw et al., "The effect of delta-9-tetrahydrocannabinol on forebrain ischemia in rat", BRAIN RES, 857(1-2), 2000, pp. 183-187

Abstract

The purpose of the study was to evaluate the effect of delta-9-tetrahydrocannabinol (THC), the major psychoactive constituent of marijuana, on ischemic neuronal injury. A 12-min ischemic insult was induced by a reduction in systolic blood pressure to a mean of 50 mm Hg, followed by bilateral carotid artery occlusion at a middle ear temperature of 37.5 degrees C, THC at either a low (0.1 mg/kg; n = 8) or high (10 mg/kg; r2 = 8) dose was injected i.p. every 12 h for 7 days prior to ischemia. Non-treated ischemic (n = 8) animals formed the control group. The animals were sacrificed 3 weeks post-ischemia for quantitative histopathology. THC at either dose did not significantly reduce ischemic neuronal damage in the hippocampus. The high dose THC-treated group showed significantly less neocortical injury, compared to either the control or low-dose THC groups (p < 0.05), The striatum was markedly protected by both low and high dose THC (p < 0.001). This regionally specific protection implies that either the hippocampus undergoes suprathreshold ischemic injury or that mechanisms of ischemic injury vary in different brain regions. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:04:56