Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SYM-2081 a kainate receptor antagonist reduces allodynia and hyperalgesia in a freeze injury model of neuropathic pain
Autore:
Ta, LE; Dionne, RA; Friction, JR; Hodges, JS; Kajander, KC;
Indirizzi:
Natl Inst Dent & Craniofacial Res, Pain & Neurosensory Mechanisms Branch, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res Bethesda MD USA 20892 sda, MD 20892 USA Univ Minnesota, Dept Diagnost & Surg Sci, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rg Sci, Minneapolis, MN 55455 USA Univ Minnesota, Oral Hlth Clin Res Ctr, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 es Ctr, Minneapolis, MN 55455 USA Univ Minnesota, Div Biostat, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 iostat, Minneapolis, MN 55455 USA Univ Minnesota, Dept Oral Sci, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 al Sci, Minneapolis, MN 55455 USA Univ Minnesota, Dept Cell Biol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 l Biol, Minneapolis, MN 55455 USA Univ Minnesota, Dept Neuroanat, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 roanat, Minneapolis, MN 55455 USA Univ Minnesota, Grad Program Neurosci, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 urosci, Minneapolis, MN 55455 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 858, anno: 2000,
pagine: 106 - 120
SICI:
0006-8993(20000306)858:1<106:SAKRAR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; SPINOTHALAMIC TRACT NEURONS; CENTRAL NERVOUS-SYSTEM; DORSAL-ROOT GANGLION; EXPERIMENTAL PERIPHERAL NEUROPATHY; SUBSTANCE-P; SPINAL-CORD; SCIATIC-NERVE; RAT MODEL; CENTRAL SENSITIZATION;
Keywords:
rat; neuropathic pain; fentanyl; excitatory amino acid; kainate receptor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Ta, LE Natl Inst Dent & Craniofacial Res, Pain & Neurosensory Mechanisms Branch, NIH, 10 Ctr Dr,Bldg 10,Room 1N-103, Bethesda, MD 20892 USA Natl InstDent & Craniofacial Res 10 Ctr Dr,Bldg 10,Room 1N-103 Bethesda MD USA 20892
Citazione:
L.E. Ta et al., "SYM-2081 a kainate receptor antagonist reduces allodynia and hyperalgesia in a freeze injury model of neuropathic pain", BRAIN RES, 858(1), 2000, pp. 106-120

Abstract

Cold-freeze injury at -4 degrees C to the rat sciatic nerve produces mechanical allodynia and thermal hyperalgesia [M.A. Kleive, P.S. Jungbluth, J.A. Uhlenkamp, K.C. Kajander, Cold injury to rat sciatic nerve induces thermalhyperalgesia or analgesia, gth World Congress on Pain, Vancouver, BC, Canada, August 1996 (Abstract).]. The NMDA receptor, an excitatory amino acid (EAA) receptor, appears to be involved in the development of allodynia and hyperalgesia following nerve injury, The role, if any, of the kainate receptor, another EAA receptor, remains unknown. In the current study, we evaluated a whether (2S,4R)-4-methylglutamic acid (SYM-2081), a recently developedkainate receptor antagonist, attenuates increased responsiveness followingcold injury to the sciatic nerve. During baseline testing, Sprague-Dawley rats were evaluated for frequency of withdrawal from van Frey filaments andlatency of withdrawal from a radiant thermal source. Animals were then anesthetized, the left sciatic nerve was exposed, and the nerve was cooled to -4 degrees C for 15 min (n = 24). For control rats (n = 24), all procedureswere identical except that the nerve was maintained at 37 degrees C. Testing resumed on the third day following surgery. On the fifth post-operative day, SYM-2081 (150 or 100 mg/kg), fentanyl citrate (0.04 mg/kg) or vehicle was injected intraperitoneally. Injury to the rat sciatic nerve induced a significant increase in withdrawal frequency and a significant decrease in withdrawal latency (ANOVA, p < 0.05). SYM-2081 and fentanyl significantly reduced these responses (p < 0.05). These results suggest that kainate and opioid receptors are involved in the mechanical allodynia and thermal hyperalgesia that develop following cold injury to the sciatic nerve. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:43:06