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Titolo:
Use of plasma glow for surface-engineering biomolecules to enhance bloodcompatibility of Dacron and PTFE vascular prosthesis
Autore:
Chandy, T; Das, GS; Wilson, RF; Rao, GHR;
Indirizzi:
Univ Minnesota, Dept Cardiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ardiol, Minneapolis, MN 55455 USA Univ Minnesota, Dept Lab Med Pathol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Pathol, Minneapolis, MN 55455 USA
Titolo Testata:
BIOMATERIALS
fascicolo: 7, volume: 21, anno: 2000,
pagine: 699 - 712
SICI:
0142-9612(200004)21:7<699:UOPGFS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET ACTIVATION; PROTEIN ADSORPTION; BLOOD; GRAFTS; FIBRINOGEN; THROMBOSIS; ADHESION; POLYMERS; HEPARIN; CELLS;
Keywords:
PTFE; Dacron vascular graft; plasma treatments; platelet adhesion; fibrinogen adsorption; FTIR; surface modification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Chandy, T Univ Minnesota, Dept Cardiol, Box 508 UMHC,420 Delaware St SE, Minneapolis, MN 55455 USA Univ Minnesota Box 508 UMHC,420 Delaware St SE Minneapolis MN USA 55455
Citazione:
T. Chandy et al., "Use of plasma glow for surface-engineering biomolecules to enhance bloodcompatibility of Dacron and PTFE vascular prosthesis", BIOMATERIAL, 21(7), 2000, pp. 699-712

Abstract

The search for a nonthrombogenic material having patency to be used for small diameter vascular graft applications continues to be a field of extensive investigation. The purpose of the present study was to examine whether surface modification of polytetra fluoroethylene (PTFE, Teflon) and polyethylene-terephthalate (Dacron) vascular grafts might extend graft biocompatibility without modifying the graft structure. A series of surface coatings were prepared by modifying the argon plasma-treated PTFE and Dacron grafts with collagen IV and laminin and subsequently immobilizing bioactive molecules like PGE(1), heparin or phosphatidyl choline via the carbodiimide functionalities. Surface analysis by Fourier transform infrared spectroscopy-attenuated total reflectance revealed the presence of new functional groups on the modified graft surfaces. In vitro studies showed that fibrinogen adsorption and platelet adhesion on modified grafts were significantly reduced. This study proposes that surface grafting of matrix components (collagen-typeIV and laminin) and subsequent immobilization of bioactive molecules (PGE(1), heparin or phosphatidyl choline) changed the surface conditioning of vascular grafts and subsequently improved their biocompatibility. However, more detailed in vivo studies are needed to confirm these observations. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:57:50