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Titolo:
Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate
Autore:
Fragonas, E; Valente, M; Pozzi-Mucelli, M; Toffanin, R; Rizzo, R; Silvestri, F; Vittur, F;
Indirizzi:
Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy Univ Trieste Trieste Italy I-34127 Chim Macromol, I-34127 Trieste, Italy Univ Trieste, Ist Clin Ortoped, I-34149 Trieste, Italy Univ Trieste Trieste Italy I-34149 Clin Ortoped, I-34149 Trieste, Italy Univ Trieste, Lab Microscopia NMR, I-34149 Trieste, Italy Univ Trieste Trieste Italy I-34149 croscopia NMR, I-34149 Trieste, Italy Univ Trieste, Ist Anat & Istol Patol, I-34149 Trieste, Italy Univ TriesteTrieste Italy I-34149 & Istol Patol, I-34149 Trieste, Italy
Titolo Testata:
BIOMATERIALS
fascicolo: 8, volume: 21, anno: 2000,
pagine: 795 - 801
SICI:
0142-9612(200004)21:8<795:ACRIRB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURE; DEFECTS; CALCIUM; GROWTH;
Keywords:
allogenic implants; chondrocytes; alginate gels; cartilage repair; NMR microscopy; SRIXE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Vittur, F Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, Via Giorgieri 1, I-34127 Trieste, Italy Univ Trieste Via Giorgieri 1 Trieste Italy I-34127 ieste, Italy
Citazione:
E. Fragonas et al., "Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate", BIOMATERIAL, 21(8), 2000, pp. 795-801

Abstract

The feasibility of allogenic implants of chondrocytes in alginate gels wastested for the reconstruction in vivo of artificially full-thickness-damaged articular rabbit cartilage. The suspensions of chondrocytes in alginate were gelled by the addition of calcium chloride solution directly into the defects giving in situ a construct perfectly inserted and adherent to the subchondral bone and to the walls of intact cartilage. The tissue repair wascontrolled at 1, 2, 4 and 6 months after the implant by NMR microscopy, synchrotron radiation induced X-ray emission to map the sulfur of glycosaminoglycans and by histochemistry. Practically a complete repair of the defect was observed 4-6 months from the implant of the chondrocytes with the recovery of a normal tissue structure. Controls in which Ca-alginate alone was implanted developed only a fibrous cartilage. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:02:34