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Titolo:
Effect of silymarin on biliary bile salt secretion in the rat
Autore:
Crocenzi, FA; Pellegrino, JM; Pozzi, EJS; Mottino, AD; Garay, EAR; Roma, MG;
Indirizzi:
Univ Nacl Rosario, CONICET, Fac Ciencias Bioquim & Farmaceut, Inst Fisiol Expt, RA-2000 Rosario, Santa Fe, Argentina Univ Nacl Rosario Rosario SantaFe Argentina RA-2000 Santa Fe, Argentina
Titolo Testata:
BIOCHEMICAL PHARMACOLOGY
fascicolo: 8, volume: 59, anno: 2000,
pagine: 1015 - 1022
SICI:
0006-2952(20000415)59:8<1015:EOSOBB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-DAMAGE; FLAVANOLIGNAN COMPLEX; ACID SYNTHESIS; CHOLESTASIS; EXCRETION; CHOLESTEROL; SILIBININ; MECHANISM; CIRRHOSIS; PROTECTS;
Keywords:
silymarin; hepatoprotection; bile secretion; bile salt output; ursodeoxycholate; muricholate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Roma, MG Univ Nacl Rosario, CONICET, Fac Ciencias Bioquim & Farmaceut, Inst Fisiol Expt, Suipacha 570, RA-2000 Rosario, Santa Fe, Argentina Univ NaclRosario Suipacha 570 Rosario Santa Fe Argentina RA-2000
Citazione:
F.A. Crocenzi et al., "Effect of silymarin on biliary bile salt secretion in the rat", BIOCH PHARM, 59(8), 2000, pp. 1015-1022

Abstract

The effect of the hepatoprotector silymarin on bile secretion, with particular regard to bile salt secretion, was studied in Wistar rats. Silymarin (25, 50, 100, and 150 mg/kg/day, i.p., for 5 days) induced a dose-dependent increase in bile flow and bile salt secretion, the maximal effect being reached at a dose of 100 mg/kg/day (+17 and +49%, for bile flow and bile salt output, respectively; P < 0.05). Assessment of bile salt composition in bile revealed that stimulation of the bile salt secretion was accounted for mainly by an increase in the biliary secretion of beta-muricholate and, to a lesser extent, of alpha-muricholate, chenodeoxycholate, ursodeoxycholate, and deoxycholate. The maximum secretory rate (T-m) of bile salts, as assessed by infusing the non-hepatotoxic bile salt tauroursodeoxycholate i.v. at stepwise-increasing rates, was not influenced by silymarin. The flavonolignan also increased the endogenous bile salt pool size (+53%, P < 0.05) and biliary bile acid excretion after bile acid pool depletion (+54%, P < 0.05), a measure of de novo bile salt synthesis. These results suggest that silymarin increases the biliary excretion and the endogenous pool of bile salts by stimulating the synthesis, among others, of hepatoprotective bile salts, such as beta-muricholate and ursodeoxycholate. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:53:30